Rabbit TTBK2 Polyclonal Antibody | anti-TTBK2 antibody

TTBK2 Rabbit Polyclonal

Cat. Num. AAA7605309

• Gene Names: TTBK2; TTBK; SCA11
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: TTBK2; Polyclonal Antibody; TTBK2 Rabbit Polyclonal; anti-TTBK2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 1244

• Applicable Applications for anti-TTBK2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Tau tubulin kinase 2
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human stomach using MBS7605309 (TTBK2 antibody) at dilution of 1:100)

Western Blot (WB)

(PC-3 cells were subjected to SDS PAGE followed by western blot with MBS7605309 (TTBK2 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 116812624
• NCBI GeneID: 146057
• NCBI Accession #: NP_775771.3
• NCBI GenBank Nucleotide #: NM_173500.3
• Molecular Weight: 54,037 Da
• NCBI Official Full Name: tau-tubulin kinase 2
• NCBI Official Synonym Full Names: tau tubulin kinase 2
• NCBI Official Symbol: TTBK2
• NCBI Official Synonym Symbols: TTBK; SCA11
• NCBI Protein Information: tau-tubulin kinase 2
• UniProt Protein Name: Tau-tubulin kinase 2
• Protein Family: Tau-tubulin kinase
• UniProt Gene Name: TTBK2
• UniProt Synonym Gene Names: KIAA0847
• UniProt Entry Name: TTBK2_HUMAN

NCBI Description

This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]

Uniprot Description

TTBK2: Serine/threonine kinase which is able to phosphorylate tau on serines. Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, CK1; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CK1 group; TTBK family

Chromosomal Location of Human Ortholog: 15q15.2

Cellular Component: centriole; cytosol; extracellular space; nucleus

Molecular Function: ATP binding; protein binding; protein serine/threonine kinase activity

Biological Process: cilium biogenesis; peptidyl-serine phosphorylation; regulation of cell shape; smoothened signaling pathway

Disease: Spinocerebellar Ataxia 11