Rabbit anti-Human, Rat TTBK2 Polyclonal Antibody | anti-TTBK2 antibody

TTBK2 Polyclonal Antibody

Cat. Num. AAA9128459

• Gene Names: TTBK2; TTBK; SCA11
• Reactivity: Human, Rat
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: TTBK2; Polyclonal Antibody; TTBK2 Polyclonal Antibody; anti-TTBK2 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Sequence Length: 478

• Applicable Applications for anti-TTBK2 antibody: Western Blot (WB)
• Application Notes: WB 1:500 - 1:2000
• Immunogen: Recombinant Protein
• Immunogen: Recombinant protein of human TTBK2
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.; Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Western Blot (WB)

(Western blot analysis of extracts of rat brain, using TTBK2 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human stomach using TTBK2 antibody at dilution of 1:200 (40x lens).)

Related Product Information for anti-TTBK2 antibody

This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem.

NCBI and Uniprot Product Information

• NCBI GI #: 116812624
• NCBI GeneID: 146057
• NCBI Accession #: NP_775771.3
• NCBI GenBank Nucleotide #: NM_173500.3
• UniProt Accession #: Q6IQ55; O94932; Q6ZN52; Q8IVV1
• Molecular Weight: 137kDa
• NCBI Official Full Name: tau-tubulin kinase 2
• NCBI Official Synonym Full Names: tau tubulin kinase 2
• NCBI Official Symbol: TTBK2
• NCBI Official Synonym Symbols: TTBK; SCA11
• NCBI Protein Information: tau-tubulin kinase 2
• UniProt Protein Name: Tau-tubulin kinase 2
• Protein Family: Tau-tubulin kinase
• UniProt Gene Name: TTBK2
• UniProt Synonym Gene Names: KIAA0847
• UniProt Entry Name: TTBK2_HUMAN

NCBI Description

This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]

Uniprot Description

TTBK2: Serine/threonine kinase which is able to phosphorylate tau on serines. Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CK1 group; TTBK family

Chromosomal Location of Human Ortholog: 15q15.2

Cellular Component: centriole; extracellular space; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding

Biological Process: regulation of cell shape; smoothened signaling pathway; peptidyl-serine phosphorylation; organelle organization and biogenesis; cilium biogenesis

Disease: Spinocerebellar Ataxia 11