Rabbit anti-Mouse TSLP Polyclonal Antibody | anti-TSLP antibody

TSLP Receptor Antibody

Cat. Num. AAA9414366

• Gene Names: Crlf2; CRLM2; Ly114; Tpte2; Tslpr
• Reactivity: Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: TSLP; Polyclonal Antibody; TSLP Receptor Antibody; TSLP Receptor; Mouse thymic stromal lymphopoietin receptor; TSLP-R; anti-TSLP antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 359

• Applicable Applications for anti-TSLP antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 21 amino acid peptide from near the center of mouse TSLP receptor.
• Target Name: TSLP Receptor
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of TSLP Receptor in mouse heart tissue lysate with TSLP Receptor antibody at 1 ug/mL in (A) the presence and (B) the absence of blocking peptide.)

Related Product Information for anti-TSLP antibody

Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. The approximately 75 kDa band seen in the immunoblot may be a post-translationally modified form of TSLP-R.

Product Categories/Family for anti-TSLP antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 257900526
• NCBI GeneID: 57914
• NCBI Accession #: NP_057924
• NCBI GenBank Nucleotide #: NM_016715.4
• Molecular Weight: 13,236 Da
• NCBI Official Full Name: cytokine receptor-like factor 2 isoform 2
• NCBI Official Synonym Full Names: cytokine receptor-like factor 2
• NCBI Official Symbol: Crlf2
• NCBI Official Synonym Symbols: CRLM2; Ly114; Tpte2; Tslpr
• NCBI Protein Information: cytokine receptor-like factor 2
• UniProt Protein Name: Cytokine receptor-like factor 2
• Protein Family: Thymic stromal lymphopoietin
• UniProt Gene Name: Crlf2
• UniProt Synonym Gene Names: Crlm2; Tpte2; Tslpr; CRLM-2; TSLP receptor
• UniProt Entry Name: CRLF2_MOUSE

Uniprot Description

CRLF2: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: membrane; cell; plasma membrane; integral to membrane; extracellular region

Molecular Function: cytokine activity

Biological Process: immunoglobulin secretion during immune response; inflammatory response