Thymic Stromal Lymphopoietin Receptor/TSP R/CRLF2 Recombinant Protein | TSPR/CRLF2 recombinant protein

Recombinant Human Thymic Stromal Lymphopoietin Receptor/TSP R/CRLF2 (C-6His)

Cat. Num. AAA2569086

• Gene Names: CRLF2; CRL2; TSLPR; CRLF2Y
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Thymic Stromal Lymphopoietin Receptor/TSP R/CRLF2; Recombinant Human Thymic Stromal Lymphopoietin Receptor/TSP R/CRLF2 (C-6His); CRL2; CRL2cytokine receptor CRL2 precusor; CRLF2; CRLF2Y; CRLM-2; Cytokine receptor-like 2; cytokine receptor-like factor 2; ILXR; IL-XR; P2RY8/CRLF2 fusion; PCOR1; TSLP R; TSLP receptor; TSLPR; TSPR/CRLF2 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Gly25-Lys231

• Species: Human
• Tag: C-6His
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Human Cytokine Receptor-Like Factor 2 is produced by our Mammalian expression system and the target gene encoding Gly25-Lys231 is expressed with a 6His tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for TSPR/CRLF2 recombinant protein

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. TSLP R expression is ubiquitous in the immune and hematopoietic cells, but is up-regulated in Th2-skewed cells. Cells expressing TSLP R alone bind TSLP with low affinity. Co-expression of TSLP R and IL-7 R alpha is required for high-affinity TSLP binding and signal transduction. The TSLP R and IL-7 R alpha are coexpressed primarily on monocytes and dendritic cells and at lower levels in lymphoid cells. TSLP has been shown to induce the release of T cell-attracting chemokines from monocytes and enhance the maturation of CD11c+ dendritic cells.

Product Categories/Family for TSPR/CRLF2 recombinant protein

immunology

NCBI and Uniprot Product Information

• NCBI GI #: 589269166
• NCBI GeneID: 64109
• NCBI Accession #: NP_001012288.2
• NCBI GenBank Nucleotide #: NM_001012288.2
• UniProt Accession #: Q9HC73; Q5G7M1; Q9H5R3; J3QKD1
• Molecular Weight: 29,360 Da
• NCBI Official Full Name: cytokine receptor-like factor 2 isoform 2
• NCBI Official Synonym Full Names: cytokine receptor-like factor 2
• NCBI Official Symbol: CRLF2
• NCBI Official Synonym Symbols: CRL2; TSLPR; CRLF2Y
• NCBI Protein Information: cytokine receptor-like factor 2; IL-XR; TSLP receptor; cytokine receptor CRL2 precusor; thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin receptor
• UniProt Protein Name: Cytokine receptor-like factor 2
• UniProt Gene Name: CRLF2
• UniProt Synonym Gene Names: CRL2; ILXR; TSLPR; TSLP receptor
• UniProt Entry Name: CRLF2_HUMAN

NCBI Description

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Uniprot Description

CRLF2: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.3; Yp11.3

Cellular Component: extracellular region; plasma membrane; integral to membrane