Rabbit anti-Human Thymic Stromal Lymphopoietin Protein Receptor Polyclonal Antibody | anti-TSLP antibody

Thymic Stromal Lymphopoietin Protein Receptor (Cytokine Receptor-Like 2, TSLP-R)

Cat. Num. AAA614551

• Gene Names: TSLP; TSLP
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Thymic Stromal Lymphopoietin Protein Receptor; Polyclonal Antibody; Thymic Stromal Lymphopoietin Protein Receptor (Cytokine Receptor-Like 2; TSLP-R); Anti -Thymic Stromal Lymphopoietin Protein Receptor (Cytokine Receptor-Like 2; anti-TSLP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human TSLP-R.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-TSLP antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Suitable for use in Western Blot, Immunofluorescence and Immunohistochemistry.; Dilution: Western Blot: 0.5-2ug/ml; Immunofluorescence: 20ug/ml; Immunohistochemistry: 5ug/ml
• Immunogen: Synthetic peptide corresponding to19aa near the center of human TSLP-R. (GenBank accession: Q9HC73).
• Positive Control: Human liver tissue lysate
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of TSLP-R in human liver tissue lysate with MBS614551 at (A) 0.5, (B) 1 and (C) 2ug/ml.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of Human liver tissue with MBS614551 (5ug/ml).)

Immunofluorescence (IF)

(Immunofluorescence of TSLP Receptor in Human Liver cells with MBS614551 at 20ug/ml.)

Related Product Information for anti-TSLP antibody

Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; cotransfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. Despite its predicted molecular weight, TSLP-R often migrates at a higher molecular weight in SDS-PAGE.

Product Categories/Family for anti-TSLP antibody

Antibodies; Abs to CD Markers

NCBI and Uniprot Product Information

• NCBI GI #: 14719428
• NCBI GeneID: 85480
• NCBI Accession #: NP_149024.1
• NCBI GenBank Nucleotide #: NM_033035.4
• UniProt Accession #: Q969D9; Q8IW99; Q96AU7
• Molecular Weight: 18,141 Da
• NCBI Official Full Name: thymic stromal lymphopoietin
• NCBI Official Synonym Full Names: thymic stromal lymphopoietin
• NCBI Official Symbol: TSLP
• NCBI Official Synonym Symbols: TSLP
• NCBI Protein Information: thymic stromal lymphopoietin; OTTHUMP00000158998; OTTHUMP00000158999
• UniProt Protein Name: Thymic stromal lymphopoietin
• Protein Family: Thymic stromal lymphopoietin
• UniProt Gene Name: TSLP
• UniProt Entry Name: TSLP_HUMAN

NCBI Description

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq]

Uniprot Description

TSLP: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5q22.1

Cellular Component: extracellular space

Molecular Function: cytokine activity