Western Blot (WB)
(Western blot analysis of extracts from 3T3, using TRPC1 Antibody. The lane on the left was treated with blocking peptide.)
Rabbit TRPC1 Polyclonal Antibody | anti-TRPC1 antibody
TRPC1 Antibody
Predicted: Pig, Zebrafish, Horse, Sheep, Rabbit, Dog, Chicken
Predicted: Pig, Zebrafish, Horse, Sheep, Rabbit, Dog, Chicken
Western Blot (WB)
(Western blot analysis of extracts from 3T3, using TRPC1 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from 3T3, using TRPC1 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from PC-3 cells, using TRPC1 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from PC-3 cells, using TRPC1 Antibody. The lane on the left was treated with blocking peptide.)
Post Translational Modifications: Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.
Subunit Structure: Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4.
Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
NCBI and Uniprot Product Information
Predicted: 92 kDa
NCBI Description
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
TRPC1: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium
Chromosomal Location of Human Ortholog: 3q23
Cellular Component: sarcomere; costamere; basolateral plasma membrane; integral to plasma membrane; plasma membrane; receptor complex; lipid raft
Molecular Function: store-operated calcium channel activity; protein binding; calcium channel activity; cation channel activity
Biological Process: axon guidance; cytosolic calcium ion homeostasis; calcium ion transport; positive regulation of release of sequestered calcium ion into cytosol; response to calcium ion; transmembrane transport; saliva secretion
Research Articles on TRPC1
Similar Products
Product Notes
The TRPC1 trpc1 (Catalog #AAA9611534) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TRPC1 Antibody reacts with Human, Mouse, Rat Predicted: Pig, Zebrafish, Horse, Sheep, Rabbit, Dog, Chicken and may cross-react with other species as described in the data sheet. AAA Biotech's TRPC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the TRPC1 trpc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRPC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
