Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Rat Transmembrane Protein 173 (TMEM173) Polyclonal Antibody | anti-TMEM173 antibody
Polyclonal Antibody to Transmembrane Protein 173 (TMEM173)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-A WSYYIGYLKL ILPGLQARIR MFNQLHNNML SGAGSRRLYI LFPLDCGVPD DLSVADPNIR FRDMLPQQNT DRAGVKNRAY SNSVYELLEN GQPAGACILE YATPLQTLFA MSQDGKAGFS REDRLEQAKL FCRTLEEILA DVPESRNHCR LIVYQESEEG NSFSLSQEVL RHIRQEEKEE VTMSGPPTSV APRPSLLSQE PRL
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
NCBI and Uniprot Product Information
Uniprot Description
STING: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Associates with the MHC-II complex. Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS/VISA and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Ubiquitously expressed. Belongs to the TMEM173 family.
Protein type: Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial
Chromosomal Location of Human Ortholog: 18p11
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral component of membrane; mitochondrial outer membrane; nucleoplasm; perinuclear region of cytoplasm; peroxisome; plasma membrane
Molecular Function: identical protein binding; protein homodimerization activity; protein kinase binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process: activation of innate immune response; apoptosis; defense response to virus; innate immune response; interferon-beta production; positive regulation of defense response to virus by host; positive regulation of interferon type I production; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter
Research Articles on TMEM173
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Product Notes
The TMEM173 tmem173 (Catalog #AAA2003913) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Transmembrane Protein 173 (TMEM173) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Transmembrane Protein 173 (TMEM173) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the TMEM173 tmem173 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-A WSYYIGYLKL ILPGLQARIR MFNQLHNNML SGAGSRRLYI LFPLDCGVPD DLSVADPNIR FRDMLPQQNT DRAGVKNRAY SNSVYELLEN GQPAGACILE YATPLQTLFA MSQDGKAGFS REDRLEQAKL FCRTLEEILA DVPESRNHCR LIVYQESEEG NSFSLSQEVL RHIRQEEKEE VTMSGPPTSV APRPSLLSQE PRL. It is sometimes possible for the material contained within the vial of "Transmembrane Protein 173 (TMEM173), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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