Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Rat Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Polyclonal Antibody | anti-CTLA4 antibody
Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- TQPSVVLASS HGVASFPCEY ASSHNTDEVR VTVLRQTNDQ VTEVCATTFT VKNTLGFLDD PFCSGTFNES RVNLTIQGLR AADTGLYFCK VELMYPPPYF VGMGNGTQIY VIDPEPCPDS DFLLWILAAV SSGLFFYSFL
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
NCBI and Uniprot Product Information
NCBI Description
immunoregulatory receptor expressed on the surface of T and B lymphocytes [RGD, Feb 2006]
Uniprot Description
CTLA-4: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Genetic variation in CTLA4 influences susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Genetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. Genetic variation in CTLA4 is the cause of susceptibility to diabetes mellitus insulin-dependent type 12 (IDDM12). A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Genetic variation in CTLA4 is the cause of susceptibility to celiac disease type 3 (CELIAC3). It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9q32
Cellular Component: clathrin-coated endocytic vesicle; external side of plasma membrane; Golgi apparatus; integral component of plasma membrane; membrane; perinuclear region of cytoplasm
Molecular Function: protein binding; receptor activity
Biological Process: B cell receptor signaling pathway; cellular response to DNA damage stimulus; immune response; negative regulation of B cell proliferation; negative regulation of immune response; negative regulation of regulatory T cell differentiation; negative regulation of T cell proliferation; positive regulation of apoptosis
Research Articles on CTLA4
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Product Notes
The CTLA4 ctla4 (Catalog #AAA2017660) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the CTLA4 ctla4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- TQPSVVLASS HGVASFPCEY ASSHNTDEVR VTVLRQTNDQ VTEVCATTFT VKNTLGFLDD PFCSGTFNES RVNLTIQGLR AADTGLYFCK VELMYPPPYF VGMGNGTQIY VIDPEPCPDS DFLLWILAAV SSGLFFYSFL. It is sometimes possible for the material contained within the vial of "Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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