Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human colon tissue slide using MBS7605124 (TPM3 Antibody) at dilution of 1:50)
Rabbit anti-Human, Mouse TPM3 Polyclonal Antibody | anti-TPM3 antibody
TPM3 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human colon tissue slide using MBS7605124 (TPM3 Antibody) at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human colon tissue slide using MBS7605124 (TPM3 Antibody) at dilution of 1:50)
Western Blot (WB)
(mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with MBS7605124 (TPM3 Antibody) at dilution of 1:600)
Western Blot (WB)
(mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with MBS7605124 (TPM3 Antibody) at dilution of 1:600)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Uniprot Description
TPM3: a cytoskeletal protein that binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Defects in TPM3 are a cause of nemaline myopathy type 1 (NEM1). Three alternatively spliced isoforms have been described.
Protein type: Actin-binding; Contractile; Cytoskeletal; Motility/polarity/chemotaxis; Motor; Oncoprotein
Chromosomal Location of Human Ortholog: 1q21.2
Cellular Component: actin filament; cytoskeleton; cytosol; muscle thin filament tropomyosin; stress fiber
Molecular Function: actin filament binding; protein binding; structural constituent of muscle
Biological Process: actin filament organization; cell motility; muscle contraction; muscle filament sliding
Disease: Myopathy, Congenital, With Fiber-type Disproportion; Nemaline Myopathy 1
Research Articles on TPM3
Similar Products
Product Notes
The TPM3 tpm3 (Catalog #AAA7605124) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TPM3 Rabbit Polyclonal reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TPM3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the TPM3 tpm3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TPM3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
