Immunohistochemistry (IHC)
(Immunochemical staining of human CSF2RB in human ovarian cancer with rabbit polyclonal antibody (1:500, formalin-fixed paraffin embedded sections).)
Rabbit anti-Mouse CD131 Polyclonal Antibody | anti-CSF2RB antibody
Anti-CD131 Antibody, Rabbit Polyclonal
Gene Names
Csf2rb; Bc; Il3r; AIC2B; Il3rb; Il5rb; CDw131; Il3rb1; Csf2rb1; Csfgmrb; AI848964
Reactivity
Mouse
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
CD131; Polyclonal Antibody; Anti-CD131 Antibody; Rabbit Polyclonal; CD131/CSF2RB/IL3RB/IL5RB Antibody; Rabbit PAb; Antigen Affinity Purified; colony stimulating factor 2 receptor; beta; low-affinity (granulocyte-macrophage); Anti-AI848964 Antibody; Anti-AIC2B Antibody; Anti-Bc Antibody; Anti-CDw131 Antibody; Anti-Csf2rb1 Antibody; Anti-Csfgmrb Antibody; Anti-Il3r Antibody; Anti-Il3rb Antibody; Anti-Il3rb1 Antibody; Anti-Il5rb Antibody; anti-CSF2RB antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Mouse CD131/CSF2RB/IL3RB/IL5RB
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-CSF2RB antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:250-1:1000
Immunogen
A synthetic peptide corresponding to the center region of the Mouse CD131/CSF2RB/IL3RB/IL5RB
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse CD131/CSF2RB/IL3RB/IL5RB, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human CSF2RB in human ovarian cancer with rabbit polyclonal antibody (1:500, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of human CSF2RB in human ovarian cancer with rabbit polyclonal antibody (1:500, formalin-fixed paraffin embedded sections).)
Related Product Information for anti-CSF2RB antibody
Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
References
Selleri S, et al. (2008) GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells. J Transl Med. 6:17.Woodcock, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13(21): 5176-85.Dirksen U, et al. (1997) Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression. J Clin Invest. 100(9): 2211-7.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
99,036 Da
NCBI Official Full Name
cytokine receptor common subunit beta
NCBI Official Synonym Full Names
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
NCBI Official Symbol
Csf2rb
NCBI Official Synonym Symbols
Bc; Il3r; AIC2B; Il3rb; Il5rb; CDw131; Il3rb1; Csf2rb1; Csfgmrb; AI848964
NCBI Protein Information
cytokine receptor common subunit beta; beta c; CD131 antigen; common beta chain; GM-CSF/IL-3/IL-5 receptor common beta-chain; GM-CSF/IL-3/IL-5 receptor common beta subunit; colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage
UniProt Protein Name
Cytokine receptor common subunit beta
Protein Family
UniProt Gene Name
Csf2rb
UniProt Synonym Gene Names
Aic2b; Csf2rb1; Il3rb1
UniProt Entry Name
IL3RB_MOUSE
Uniprot Description
CSF2RB: a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. A type I cytokine family of receptor. Defects are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.
Protein type: Receptor, cytokine; Membrane protein, integral
Cellular Component: membrane; integral to membrane
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding
Biological Process: cytokine and chemokine mediated signaling pathway
Research Articles on CSF2RB
Similar Products
Product Notes
The CSF2RB csf2rb (Catalog #AAA8101611) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD131 Antibody, Rabbit Polyclonal reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD131 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:250-1:1000. Researchers should empirically determine the suitability of the CSF2RB csf2rb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD131, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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