Western Blot (WB)
((0.3ug/ml) staining of Human Brain (Cerebellum) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat TOM1L1/SRCASM Polyclonal Antibody | anti-TOM1L1 antibody
Goat anti-TOM1L1/SRCASM Antibody
Western Blot: Approx 48kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 53. 0kDa according to NP_005477.1). Recommended concentration: 0.3-1ug/ml.
Western Blot (WB)
((0.3ug/ml) staining of Human Brain (Cerebellum) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
((0.3ug/ml) staining of Human Brain (Cerebellum) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
Uniprot Description
Srcasm: an adapter protein that is a src-family kinase substrate. When phosphorylated, it binds src-family kinases and targets them for lysosomal-dependent degradation. EGF triggers a transient association of phosphorylated Srcasm with EGFR via Grb2 and Shc initiating the endocytosis of the ligand-receptor complex. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. Involved in multivesicular body (MVB) formation, viral egress from the cell, and cytokinesis. Belongs to the TOM1 family. Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. The PTAP sequence in the GAT domain and the PSAP sequence in the C-terminal region are responsible for its interaction with the UEV domain of Tsg101, a component of the ESCRT-1 complex. Localizes to the multivesicular body (MVB) that is involved in targeting endosomal proteins for lysosomal degradation.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17q23.2
Cellular Component: cytoplasm; cytosol; endosome; endosome membrane; Golgi stack; lysosome
Molecular Function: clathrin binding; protein binding; protein kinase activator activity; protein kinase binding; SH3 domain binding; ubiquitin binding
Biological Process: activation of protein kinase activity; intracellular protein transport; negative regulation of mitosis; positive regulation of protein amino acid autophosphorylation; signal transduction; ubiquitin-dependent protein catabolic process via the multivesicular body pathway
Research Articles on TOM1L1
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Product Notes
The TOM1L1 tom1l1 (Catalog #AAA421611) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-TOM1L1/SRCASM Antibody reacts with Tested: Human; Expected from sequence similarity: Human and may cross-react with other species as described in the data sheet. AAA Biotech's TOM1L1/SRCASM can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Approx 48kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 53. 0kDa according to NP_005477.1). Recommended concentration: 0.3-1ug/ml. Researchers should empirically determine the suitability of the TOM1L1 tom1l1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: EQNKNQKEAT NTTSE. It is sometimes possible for the material contained within the vial of "TOM1L1/SRCASM, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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