Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse Toll Like Receptor 2 Polyclonal Antibody | anti-TLR2 antibody
Polyclonal Antibody to Toll Like Receptor 2 (TLR2)
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue))
NCBI and Uniprot Product Information
Uniprot Description
TLR2: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage- activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1. Interacts with CNPY3. Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. Belongs to the Toll-like receptor family.
Protein type: Apoptosis; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 3|3 E3
Cellular Component: cell projection; cell surface; cytoplasm; cytoplasmic vesicle; external side of plasma membrane; Golgi apparatus; integral component of membrane; intrinsic component of plasma membrane; membrane; membrane raft; plasma membrane
Molecular Function: diacyl lipopeptide binding; lipopolysaccharide binding; peptidoglycan binding; protein binding; protein complex binding; protein heterodimerization activity; receptor activity; signaling pattern recognition receptor activity; triacyl lipopeptide binding
Biological Process: cell activation; cell surface pattern recognition receptor signaling pathway; chloramphenicol transport; cytokine secretion involved in immune response; defense response to Gram-positive bacterium; detection of diacyl bacterial lipopeptide; detection of triacylated bacterial lipoprotein; I-kappaB phosphorylation; immune system process; induction by symbiont of defense-related host nitric oxide production; inflammatory response; innate immune response; interleukin-10 production; learning; leukotriene metabolic process; microglia development; microglial cell activation; MyD88-dependent toll-like receptor signaling pathway; myelin formation in the central nervous system; negative regulation of actin filament polymerization; negative regulation of cell proliferation; negative regulation of interleukin-12 production; negative regulation of interleukin-17 production; negative regulation of phagocytosis; negative regulation of synaptogenesis; nitric oxide metabolic process; positive regulation of chemokine production; positive regulation of cytokine secretion; positive regulation of inflammatory response; positive regulation of interferon-beta production; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-18 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of leukocyte migration; positive regulation of NF-kappaB import into nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of oligodendrocyte differentiation; positive regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor production; positive regulation of Wnt receptor signaling pathway; regulation of cytokine secretion; regulation of dendritic cell cytokine production; response to bacterial lipoprotein; response to bacterium; response to molecule of bacterial origin; response to molecule of fungal origin; response to peptidoglycan; signal transduction; toll-like receptor 2 signaling pathway; toll-like receptor signaling pathway; tumor necrosis factor production
Research Articles on TLR2
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Product Notes
The TLR2 tlr2 (Catalog #AAA2028007) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Toll Like Receptor 2 (TLR2) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Toll Like Receptor 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the TLR2 tlr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Toll Like Receptor 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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