Rabbit TNFSF18 Polyclonal Antibody | anti-TNFSF18 antibody

TNFSF18 Polyclonal Antibody

Cat. Num. AAA3007709

• Gene Names: TNFSF18; TL6; AITRL; GITRL; TNLG2A; hGITRL
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TNFSF18; Polyclonal Antibody; TNFSF18 Polyclonal Antibody; Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL; anti-TNFSF18 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TNFSF18 pAb detects endogenous levels of TNFSF18 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 199

• Applicable Applications for anti-TNFSF18 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding Human TNFSF18.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of TNFSF18 pAb at 1:1000 dilutionLane1:SK-OVCAR3 whole cell lysate (40ug) Lane2:HEK293T whole cell lysate (40ug) Lane3:The Testis tissue lysate of Mouse (40ug) Lane4:The Testis tissue lysate of Rat (40ug))

Related Product Information for anti-TNFSF18 antibody

GITRL (glucocorticoid-induced TNF-related ligand), a polypeptide encoded by a human umbilical endothelial cell cDNA, is a member of the TNF (tumor necrosis factor) superfamily. GITRL has a type 2 transmembrane topology that is characteristic of the TNF family. The TNF superfamilies regulate diverse biological functions, including cell proliferation, differentiation and survival. GITRL is found on vascular endothelial cells and in several peripheral tissues (small intestine, ovary, testis and kidney), where it may modulate T lymphocyte survival. The GITR receptor recognizes GITRL and the two interact to regulate NFkappaB activation. The ligand-receptor pair of GITRL-GITR protects cells against AICD (activation-induced cell death).

NCBI and Uniprot Product Information

• NCBI GI #: 157419142
• NCBI GeneID: 8995
• NCBI Accession #: NP_005083.2
• NCBI GenBank Nucleotide #: NP_005083.2
• UniProt Accession #: Q9UNG2
• Molecular Weight: ~ 22kDa
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 18
• NCBI Official Synonym Full Names: TNF superfamily member 18
• NCBI Official Symbol: TNFSF18
• NCBI Official Synonym Symbols: TL6; AITRL; GITRL; TNLG2A; hGITRL
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 18
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 18
• Protein Family: Tumor necrosis factor ligand superfamily
• UniProt Gene Name: TNFSF18
• UniProt Synonym Gene Names: AITRL; GITRL; TL6; AITRL; hGITRL
• UniProt Entry Name: TNF18_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]

Uniprot Description

TNFSF18: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Belongs to the tumor necrosis factor family.

Protein type: Membrane protein, integral; Apoptosis; Cytokine

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: extracellular space; cell surface; plasma membrane; integral to membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding

Biological Process: tumor necrosis factor-mediated signaling pathway; cell-cell signaling; T cell proliferation during immune response; regulation of T cell proliferation; signal transduction; negative regulation of apoptosis; activation of NF-kappaB transcription factor