AITRL (TNFSF18) Recombinant Protein | AITRL recombinant protein

Recombinant Human AITRL (TNFSF18)

Cat. Num. AAA4159789

• Gene Names: TNFSF18; TL6; AITRL; GITRL; TNLG2A; hGITRL
• Purity: >95% as determined by SDS-PAGE
• Synonyms: AITRL (TNFSF18); Recombinant Human AITRL (TNFSF18); Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; GITRL; hGITRL; Tumor necrosis factor ligand superfamily member 18; TNFSF18; TL-6; Recombinant Human Activation-Induced TNFR Member Ligand (TNFSF18); AITRL recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from a 0.2 micron filtered solution in Tris and salt
• Sequence Length: 199

• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method.
• Reconstitution: Reconstitute at 0.1 mg/mL in PBS containing at least 0.1% human or bovine serum albumin.
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Testing Data

Testing Data

Related Product Information for AITRL recombinant protein

TNFSF18 is a transmembrane glycoprotein which is expressed in vascular endothelial cells as well as neurons, antigen presenting cells, CD4‚--CD8‚-double negative thymic precursors, and in the eye. TNFSF18 works to mediate the interactions between T cells and endothelial cells, and T cell growth. It has been shown that TNFSF18's expression is transiently up-regulated by proinflammatory stimulation.

NCBI and Uniprot Product Information

• NCBI GI #: 157419142
• NCBI GeneID: 8995
• NCBI Accession #: NP_005083.2
• NCBI GenBank Nucleotide #: NP_005083.2
• UniProt Accession #: Q9UNG2
• Molecular Weight: 14.2 kDa
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 18
• NCBI Official Synonym Full Names: TNF superfamily member 18
• NCBI Official Symbol: TNFSF18
• NCBI Official Synonym Symbols: TL6; AITRL; GITRL; TNLG2A; hGITRL
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 18
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 18
• UniProt Gene Name: TNFSF18
• UniProt Synonym Gene Names: AITRL; GITRL; TL6; AITRL; hGITRL
• UniProt Entry Name: TNF18_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]

Uniprot Description

TNFSF18: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Belongs to the tumor necrosis factor family.

Protein type: Membrane protein, integral; Apoptosis; Cytokine

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: extracellular space; cell surface; plasma membrane; integral to membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding

Biological Process: tumor necrosis factor-mediated signaling pathway; cell-cell signaling; T cell proliferation during immune response; regulation of T cell proliferation; signal transduction; negative regulation of apoptosis; activation of NF-kappaB transcription factor