Rabbit TNFRSF17 Polyclonal Antibody | anti-TNFRSF17 antibody

TNFRSF17 Polyclonal Antibody

Cat. Num. AAA3006854

• Gene Names: TNFRSF17; BCM; BCMA; CD269; TNFRSF13A
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TNFRSF17; Polyclonal Antibody; TNFRSF17 Polyclonal Antibody; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269; BCM; BCMA; anti-TNFRSF17 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TNFRSF17 polyclonal antibody detects endogenous levels of TNFRSF17 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 184

• Applicable Applications for anti-TNFRSF17 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human TNFRSF17
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of TNFRSF17 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysate (40ug) Lane2:U-87MG whole cell lysate (40ug) Lane3:The Spleen tissue lysate of Mouse (40ug) Lane4:PC12 whole cell lysate (40ug))

Related Product Information for anti-TNFRSF17 antibody

The B cell maturation protein (BCMA), also designated BCM and tumor necrosis factor receptor superfamily, member 17, is a type I integral membrane protein located on chromosome band 16p13.1 that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).

NCBI and Uniprot Product Information

• NCBI GI #: 23238192
• NCBI GeneID: 608
• NCBI Accession #: NP_001183.2
• NCBI GenBank Nucleotide #: NP_001183.2
• UniProt Accession #: Q02223
• Molecular Weight: ~ 20kDa
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 17
• NCBI Official Synonym Full Names: TNF receptor superfamily member 17
• NCBI Official Symbol: TNFRSF17
• NCBI Official Synonym Symbols: BCM; BCMA; CD269; TNFRSF13A
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 17
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 17
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF17
• UniProt Synonym Gene Names: BCM; BCMA
• UniProt Entry Name: TNR17_HUMAN

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

Uniprot Description

TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Protein type: Membrane protein, integral; Oncoprotein; Receptor, misc.

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: integral to membrane; plasma membrane; endomembrane system

Molecular Function: receptor activity

Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction