Rabbit anti-Human, Mouse TMEM59 Polyclonal Antibody | anti-TMEM59 antibody

TMEM59 Antibody

Cat. Num. AAA9629443

• Gene Names: TMEM59; C1orf8; HSPC001
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: TMEM59; Polyclonal Antibody; TMEM59 Antibody; C1orf8; HSPC001; Liver membrane-bound protein; TMEM59 transmembrane protein 59; TMM59_HUMAN; Transmembrane protein 59; anti-TMEM59 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: TMEM59 Antibody detects endogenous levels of total TMEM59.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-TMEM59 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy. Belongs to the TMEM59 family.
• Post Translational Modifications: N-glycosylated.
• Subunit Structure: Interacts with ATG16L1 (via WD repeats).
• Function: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
• Note: Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-TMEM59 antibody

Late endosome membrane; Single-pass type I membrane protein; Lysosome membrane; Cell membrane; Golgi apparatus membrane; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 20070191
• NCBI GeneID: 9528
• NCBI Accession #: NP_004863
• NCBI GenBank Nucleotide #: NM_004872.3
• UniProt Accession #: Q9BXS4; O75393; Q4VBP9; Q5T705; Q96KX7; B3KQL7
• Molecular Weight: 36,223 Da
• NCBI Official Full Name: transmembrane protein 59
• NCBI Official Synonym Full Names: transmembrane protein 59
• NCBI Official Symbol: TMEM59
• NCBI Official Synonym Symbols: C1orf8; HSPC001
• NCBI Protein Information: transmembrane protein 59; liver membrane-bound protein
• UniProt Protein Name: Transmembrane protein 59
• Protein Family: Transmembrane protein
• UniProt Gene Name: TMEM59
• UniProt Synonym Gene Names: C1orf8
• UniProt Entry Name: TMM59_HUMAN

NCBI Description

This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Description

TMEM59: Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. Belongs to the TMEM59 family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p32.3

Cellular Component: Golgi membrane; lysosome; Golgi trans cisterna; lysosomal membrane; late endosome membrane; late endosome; integral to membrane; plasma membrane; Golgi cis cisterna; Golgi medial cisterna

Molecular Function: protein binding; endopeptidase activity

Biological Process: autophagy; proteolysis; positive regulation of autophagy