Rabbit TMEM59 Polyclonal Antibody | anti-TMEM59 antibody

TMEM59 Polyclonal Antibody

Cat. Num. AAA3015234

• Gene Names: TMEM59; C1orf8; HSPC001
• Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: TMEM59; Polyclonal Antibody; TMEM59 Polyclonal Antibody; C1orf8; HSPC001; Liver membrane-bound protein; TMEM59 transmembrane protein 59; TMM59_HUMAN; Transmembrane protein 59. ; anti-TMEM59 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit
• Clonality: Polyclonal
• Specificity: TMEM59 Polyclonal Antibody detects endogenous levels of TMEM59 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-TMEM59 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from human TMEM59:141-240/323
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Testing Data

(Primary: Anti- TMEM59 at 1/1000 dilution)

Related Product Information for anti-TMEM59 antibody

TMEM59 is a 144 amino acid protein encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

NCBI and Uniprot Product Information

• NCBI GI #: 20070191
• NCBI GeneID: 9528
• NCBI Accession #: NP_004863
• NCBI GenBank Nucleotide #: NM_004872.3
• UniProt Accession #: Q9BXS4; O75393; Q4VBP9; Q5T705; Q96KX7; B3KQL7
• Molecular Weight: 36,223 Da
• NCBI Official Full Name: transmembrane protein 59
• NCBI Official Synonym Full Names: transmembrane protein 59
• NCBI Official Symbol: TMEM59
• NCBI Official Synonym Symbols: C1orf8; HSPC001
• NCBI Protein Information: transmembrane protein 59; liver membrane-bound protein
• UniProt Protein Name: Transmembrane protein 59
• Protein Family: Transmembrane protein
• UniProt Gene Name: TMEM59
• UniProt Synonym Gene Names: C1orf8
• UniProt Entry Name: TMM59_HUMAN

NCBI Description

This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Description

TMEM59: Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. Belongs to the TMEM59 family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p32.3

Cellular Component: Golgi membrane; lysosome; Golgi trans cisterna; lysosomal membrane; late endosome membrane; late endosome; integral to membrane; plasma membrane; Golgi cis cisterna; Golgi medial cisterna

Molecular Function: protein binding; endopeptidase activity

Biological Process: autophagy; proteolysis; positive regulation of autophagy