Rabbit anti-Human TLR10 Polyclonal Antibody | anti-TLR10 antibody

TLR10 Antibody

Cat. Num. AAA9629259

• Gene Names: TLR10; CD290
• Reactivity: Human
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: TLR10; Polyclonal Antibody; TLR10 Antibody; CD 290; CD 290 antigen; CD290; CD290 antigen; MGC104967; MGC126398; MGC126399; OTTHUMP00000158729; OTTHUMP00000218162; TLR10_HUMAN; Toll like receptor 10; Toll-like receptor 10; UNQ315/PRO358; anti-TLR10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: TLR10 Antibody detects endogenous levels of total TLR10.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-TLR10 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. Belongs to the Toll-like receptor family.
• Subunit Structure: Binds MYD88 via their respective TIR domains (By similarity). Homodimer (Potential).
• Tissue Specificity: Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.
• Function: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-TLR10 antibody

Membrane; Single-pass type I membrane protein; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 37181720
• NCBI GeneID: 81793
• UniProt Accession #: Q9BXR5; Q32MI7; Q32MI8; Q5FWG4; Q6UXL3; A8K7L1; B3Y668; D1CS21; D1CS22
• Molecular Weight: 94,564 Da
• NCBI Official Full Name: TLR10
• NCBI Official Synonym Full Names: toll-like receptor 10
• NCBI Official Symbol: TLR10
• NCBI Official Synonym Symbols: CD290
• NCBI Protein Information: toll-like receptor 10
• UniProt Protein Name: Toll-like receptor 10
• Protein Family: Toll-like receptor
• UniProt Gene Name: TLR10
• UniProt Entry Name: TLR10_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Uniprot Description

TLR10: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: transmembrane receptor activity

Biological Process: toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of cytokine secretion; toll-like receptor signaling pathway; innate immune response; immune response; inflammatory response; positive regulation of inflammatory response; toll-like receptor 10 signaling pathway