Rabbit anti-Human, Mouse TIMM17A Polyclonal Antibody | anti-TIMM17A antibody

TIMM17A Polyclonal Antibody

Cat. Num. AAA3011579

• Gene Names: TIMM17A; TIM17; TIM17A
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TIMM17A; Polyclonal Antibody; TIMM17A Polyclonal Antibody; Mitochondrial import inner membrane translocase subunit Tim17-A; Inner membrane preprotein translocase Tim17a; MIMT17; TIM17; TIM17A; TIMM17; anti-TIMM17A antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TIMM17A polyclonal antibody detects endogenous levels of TIMM17A protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 171

• Applicable Applications for anti-TIMM17A antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: Recombinant full length Human TIMM17A.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of TIMM17A polyclonal antibody)

Related Product Information for anti-TIMM17A antibody

Translocation of nuclear encoded preproteins into the mitochondrial matrix requires the coordinated action of the translocases Tom and Tim, which are located in the outer mitochondrial membrane and the inner membrane, respectively. The mitochondrial preprotein translocases of the outer membrane (Tom) is a multi-subunit protein that contains at least eight proteins: four import receptor subunits (Tom70, Tom37, Tom22, and Tom20), three small proteins (Tom7, Tom6, and Tom5), and a structural component of the outer membrane channel (Tom40). The Tom machinery involves the import receptors, which initiate the binding of cytosolically synthesized preproteins to the outer membrane, and a general import pore (GIP), which promotes the translocation of various pre-proteins into the mitochondria. The TIM channel imports nuclear-encoded mitochondrial preproteins, and it involves three proteins, Tim17, Tim23 and Tim44, which are represented at equimolar ratios. Tim17 is expressed as two isoforms Tim17a and Tim17b, which differ only in their C termini sequences, and like Tim23, these proteins are ubiquitously expressed in fetal and adult tissues. Tim17 and Tim23 are integral membrane proteins that comprise the structural elements of the inner membrane channel by which the preproteins are transferred. The Tim44, on the other hand, is a largely hydrophilic protein that recruits the matrix located Hsp70 to the site where the preprotein emerges from the Tim channel.

NCBI and Uniprot Product Information

• NCBI GI #: 5454120
• NCBI GeneID: 10440
• NCBI Accession #: NP_006326.1
• NCBI GenBank Nucleotide #: NP_006326.1
• UniProt Accession #: Q99595
• Molecular Weight: ~ 18kDa
• NCBI Official Full Name: mitochondrial import inner membrane translocase subunit Tim17-A
• NCBI Official Synonym Full Names: translocase of inner mitochondrial membrane 17A
• NCBI Official Symbol: TIMM17A
• NCBI Official Synonym Symbols: TIM17; TIM17A
• NCBI Protein Information: mitochondrial import inner membrane translocase subunit Tim17-A
• UniProt Protein Name: Mitochondrial import inner membrane translocase subunit Tim17-A
• Protein Family: Mitochondrial import inner membrane translocase
• UniProt Gene Name: TIMM17A
• UniProt Synonym Gene Names: MIMT17; TIM17; TIM17A; TIMM17

Uniprot Description

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.