Rabbit anti-Human, Mouse TIA1 Polyclonal Antibody | anti-TIA1 antibody

TIA1 Polyclonal Antibody

Cat. Num. AAA2562125

• Gene Names: TIA1; WDM; TIA-1
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: TIA1; Polyclonal Antibody; TIA1 Polyclonal Antibody; Cytotoxic granule associated RNA binding protein 1; Cytotoxic granule associated RNA binding protein; MTIA-1; Nucleolysin TIA 1 isoform p40; Nucleolysin TIA-1 isoform p40; Nucleolysin TIA1 isoform p40; P40 TIA 1; P40-TIA-1 (containing p15-TIA-1); P40-TIA-1; RNA binding protein TIA 1; RNA binding protein TIA1; RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; TIA 1; TIA 1 cytotoxic granule associated RNA binding protein; Tia; TIA-1; TIA1 cytotoxic granule associated RNA binding protein; TIA1 cytotoxic granule associated RNA binding protein like 1; TIA1 protein; TIAL1; TIAR; WDM; anti-TIA1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 386

• Applicable Applications for anti-TIA1 antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:1000-1:5000; IHC: 1:40-1:250; ELISA: 1:5000-1:10000
• Immunogen: Full length fusion protein
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of HEPG2 and NIH/3T3 cell lysates using TIA1 Polyclonal Antibody at dilution of 1:600)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using TIA1 Polyclonal Antibody at dilution of 1:55(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human tonsil tissue using TIA1 Polyclonal Antibody at dilution of 1:55(×200))

Related Product Information for anti-TIA1 antibody

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.

Product Categories/Family for anti-TIA1 antibody

Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 206729905
• NCBI GeneID: 7072
• UniProt Accession #: P31483
• Molecular Weight: 43 kDa
• NCBI Official Full Name: Nucleolysin TIA-1 isoform p40
• NCBI Official Synonym Full Names: TIA1 cytotoxic granule associated RNA binding protein
• NCBI Official Symbol: TIA1
• NCBI Official Synonym Symbols: WDM; TIA-1
• NCBI Protein Information: nucleolysin TIA-1 isoform p40; nucleolysin TIA-1
• UniProt Protein Name: Nucleolysin TIA-1 isoform p40
• Protein Family: Nucleolysin
• UniProt Gene Name: TIA1
• UniProt Synonym Gene Names: TIA-1
• UniProt Entry Name: TIA1_HUMAN

NCBI Description

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]

Uniprot Description

TIA1: Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation; RNA-binding

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: nucleoplasm; stress granule; cytoplasm

Molecular Function: protein binding; nucleotide binding; AU-rich element binding; poly(A) binding

Biological Process: regulation of nuclear mRNA splicing, via spliceosome; apoptosis; negative regulation of translation; negative regulation of cytokine biosynthetic process

Disease: Welander Distal Myopathy