Western Blot (WB)
(Anti-TIA1 antibody, MBS176792, Western blottingLane 1: JURKAT Cell LysateLane 2: RAJI Cell LysateLane 3: CEM Cell LysateLane 4: HT1080 Cell LysateLane 5: K562 Cell Lysate )
Rabbit anti-Human, Mouse TIA1 Polyclonal Antibody | anti-TIA1 antibody
Anti-TIA1 antibody
Western Blot (WB)
(Anti-TIA1 antibody, MBS176792, Western blottingLane 1: JURKAT Cell LysateLane 2: RAJI Cell LysateLane 3: CEM Cell LysateLane 4: HT1080 Cell LysateLane 5: K562 Cell Lysate )
Western Blot (WB)
(Anti-TIA1 antibody, MBS176792, Western blottingLane 1: JURKAT Cell LysateLane 2: RAJI Cell LysateLane 3: CEM Cell LysateLane 4: HT1080 Cell LysateLane 5: K562 Cell Lysate )
Background: TIA1, also called WDM, encodes an RNA-binding protein involved in splicing regulation and translational repression. The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte(CTL) target cells. By in situ hybridization, this gene is mapped to chromosome 2p13.3. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is though to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
NCBI and Uniprot Product Information
NCBI Description
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008]
Uniprot Description
TIA1: Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Translation; RNA-binding
Chromosomal Location of Human Ortholog: 2p13
Cellular Component: nucleoplasm; stress granule; cytoplasm
Molecular Function: protein binding; nucleotide binding; AU-rich element binding; poly(A) binding
Biological Process: regulation of nuclear mRNA splicing, via spliceosome; apoptosis; negative regulation of translation; negative regulation of cytokine biosynthetic process
Disease: Welander Distal Myopathy
Research Articles on TIA1
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Product Notes
The TIA1 tia1 (Catalog #AAA176792) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TIA1 antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TIA1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TIA1 tia1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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