Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using THAP1 antibody.)
Rabbit THAP1 Polyclonal Antibody | anti-THAP1 antibody
THAP1 Polyclonal Antibody
IHC: 1:50-1:200
IF: 1:50-1:200
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using THAP1 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using THAP1 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat heart with THAP1 Polyclonal Antibody)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat heart with THAP1 Polyclonal Antibody)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded mouse heart with THAP1 Polyclonal Antibody)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded mouse heart with THAP1 Polyclonal Antibody)
NCBI and Uniprot Product Information
Observed MW: 25kDa
NCBI Description
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Uniprot Description
THAP1: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. Defects in THAP1 are the cause of dystonia type 6 (DYT6). DYT6 is a primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions. Belongs to the THAP1 family.
Protein type: DNA-binding; Transcription factor; Cell cycle regulation
Chromosomal Location of Human Ortholog: 8p11.21
Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus; PML body
Molecular Function: identical protein binding; protein binding; sequence-specific DNA binding; zinc ion binding
Biological Process: cell cycle; endothelial cell proliferation; regulation of mitotic cell cycle; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Disease: Dystonia 6, Torsion
Research Articles on THAP1
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Product Notes
The THAP1 thap1 (Catalog #AAA2537538) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The THAP1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's THAP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200. Researchers should empirically determine the suitability of the THAP1 thap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "THAP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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