Western Blot (WB)
(RNF6 antibody (MBS833977) used at 0.2-1 ug/ml to detect target protein.)
Rabbit RNF6 Polyclonal Antibody | anti-RNF6 antibody
RNF6 antibody
Western Blot (WB)
(RNF6 antibody (MBS833977) used at 0.2-1 ug/ml to detect target protein.)
Western Blot (WB)
(RNF6 antibody (MBS833977) used at 0.2-1 ug/ml to detect target protein.)
Immunohistochemistry (IHC)
(RNF6 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of intestinal villus (arrows) in Mouse Intestine. Magnification is at 400X)
Immunohistochemistry (IHC)
(RNF6 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of intestinal villus (arrows) in Mouse Intestine. Magnification is at 400X)
NCBI and Uniprot Product Information
Uniprot Description
RNF6: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. Defects in RNF6 may be a cause of esophageal cancer (ESCR). A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Belongs to the RNF12 family.
Protein type: EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; Ligase
Cellular Component: PML body; nuclear membrane; cell projection; intracellular membrane-bound organelle; axon; cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; androgen receptor binding; zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; metal ion binding; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; ubiquitin-protein ligase activity; ribosomal S6-glutamic acid ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein ubiquitination; negative regulation of axon extension
Research Articles on RNF6
Similar Products
Product Notes
The RNF6 rnf6 (Catalog #AAA833977) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's RNF6 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). WB: 1.25 ug/ml. Researchers should empirically determine the suitability of the RNF6 rnf6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RNF6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
