Rabbit anti-Human, Mouse TFAP2B Polyclonal Antibody | anti-TFAP2B antibody

TFAP2B Antibody

Cat. Num. AAA9402098

• Gene Names: TFAP2B; AP-2B; AP2-B
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Antigen affinity purification.
• Synonyms: TFAP2B; Polyclonal Antibody; TFAP2B Antibody; AP-2B; AP2-B; anti-TFAP2B antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total TFAP2B protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.5 mg/ml (varies by lot)
• Sequence Length: 460

• Applicable Applications for anti-TFAP2B antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:200-1:1000
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the N terminal of human transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
• Target Name: TFAP2B
• Preparation and Storage: Store at -20 degree C

Testing Data

(Gel: 10%SDS-PAGE Lysate: 40ug Jurkat cell Primary antibody: 1/416.6 dilution Secondary antibody dilution: 1/8000 Exposure time: 40 seconds)

Related Product Information for anti-TFAP2B antibody

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.

Product Categories/Family for anti-TFAP2B antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 118582289
• NCBI GeneID: 7021
• NCBI Accession #: NP_003212.2
• NCBI GenBank Nucleotide #: NM_003221.3
• UniProt Accession #: Q92481; Q5JYX6; Q9NQ63; Q9NU99; Q9UJI7; Q9Y214; Q9Y3K3
• Molecular Weight: 51,524 Da
• NCBI Official Full Name: transcription factor AP-2-beta
• NCBI Official Synonym Full Names: transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
• NCBI Official Symbol: TFAP2B
• NCBI Official Synonym Symbols: AP-2B; AP2-B
• NCBI Protein Information: transcription factor AP-2-beta
• UniProt Protein Name: Transcription factor AP-2-beta
• Protein Family: Transcription factor
• UniProt Gene Name: TFAP2B
• UniProt Synonym Gene Names: AP2-beta
• UniProt Entry Name: AP2B_HUMAN

NCBI Description

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]

Uniprot Description

AP-2 beta: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Belongs to the AP-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: nucleus

Molecular Function: protein dimerization activity; protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; transcription coactivator activity; caspase inhibitor activity; chromatin binding; transcription factor activity; transcription corepressor activity

Biological Process: fat cell differentiation; transcription from RNA polymerase II promoter; skin development; hindlimb morphogenesis; response to lithium ion; positive regulation of transcription, DNA-dependent; regulation of BMP signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of caspase activity; glucose homeostasis; forelimb morphogenesis; calcium ion homeostasis; negative regulation of cell proliferation; sympathetic nervous system development; regulation of transcription, DNA-dependent; regulation of cell differentiation; positive regulation of neuron apoptosis; positive regulation of cell proliferation; sodium ion homeostasis; phosphate ion homeostasis; negative regulation of neuron apoptosis; kidney development; potassium ion homeostasis; response to drug; glucose metabolic process; renal water homeostasis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of insulin secretion; negative regulation of apoptosis

Disease: Char Syndrome