Rabbit anti-Human TAC4 Polyclonal Antibody | anti-TAC4 antibody

TAC4, CT (TAC4, Tachykinin-4, Preprotachykinin-C, Endokinin-A, Endokinin-A/B, Endokinin-C) (AP)

Cat. Num. AAA6353226

• Gene Names: TAC4; EK; HK1; HK-1; PPT-C
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TAC4; Polyclonal Antibody; CT (TAC4; Tachykinin-4; Preprotachykinin-C; Endokinin-A; Endokinin-A/B; Endokinin-C) (AP); Endokinin-C; anti-TAC4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-TAC4 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TAC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-113 amino acids from the C-terminal region of human TAC4.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(TAC4 Antibody (C-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the TAC4 antibody detected the TAC4 protein (arrow).)

Related Product Information for anti-TAC4 antibody

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-TAC4 antibody

Antibodies; Proteins

References

Klassert, T.E., et al. J. Neuroimmunol. 227 (1-2), 202-207 (2010): Tran, A.H., et al. Neuropeptides 43(1):1-12(2009). Cunningham, S., et al. J. Neuroimmunol. 183 (1-2), 208-213 (2007): Page, N.M. Vascul. Pharmacol. 45(4):200-208(2006). Page, N.M. Cell. Mol. Life Sci. 61(13):1652-1663(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 117938258
• NCBI GeneID: 255061
• NCBI Accession #: NP_001070971.1; NP_001070974.1; NP_001070972.1; NP_733786.2; NP_001070973.1
• NCBI GenBank Nucleotide #: NM_001077503.1
• UniProt Accession #: Q86UU9; Q2M2P1; Q6ECK8; Q86UU6; Q86UU7; Q86UU8; Q8IWZ7
• Molecular Weight: 12,305 Da
• NCBI Official Full Name: tachykinin-4 isoform beta
• NCBI Official Synonym Full Names: tachykinin 4 (hemokinin)
• NCBI Official Symbol: TAC4
• NCBI Official Synonym Symbols: EK; HK1; HK-1; PPT-C
• NCBI Protein Information: tachykinin-4; endokinin; preprotachykinin-C
• UniProt Protein Name: Tachykinin-4
• Protein Family: Tachykinin
• UniProt Gene Name: TAC4
• UniProt Synonym Gene Names: PPT-C; EKA; EKA/B; EKC
• UniProt Entry Name: TKN4_HUMAN

Uniprot Description

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility. Ref.1 Ref.7 Ref.8 Ref.9

Subcellular location: Secreted

Probable.

Tissue specificity: Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta. Ref.1 Ref.6

Sequence similarities: Belongs to the tachykinin family.

Sequence caution: The sequence AAI00841.1 differs from that shown. Reason: Intron retention.The sequence AAI00843.1 differs from that shown. Reason: Intron retention.The sequence AAI00844.1 differs from that shown. Reason: Intron retention.The sequence AAN77128.1 differs from that shown. Reason: Intron retention.The sequence EAW94657.1 differs from that shown. Reason: Erroneous gene model prediction.