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Western Blot (WB) (Western blot analysis of SYNGR3 in mouse brain tissue lysate with SYNGR3 antibody at (A) 1 and (B) 2 μg/mL .)

Rabbit SYNGR3 Polyclonal Antibody | anti-SYNGR3 antibody

SYNGR3 Antibody

Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
SYNGR3 Antibody is affinity chromatography purified via peptide column.
Synonyms
SYNGR3; Polyclonal Antibody; SYNGR3 Antibody; Synaptogyrin-3; synaptogyrin 3; anti-SYNGR3 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
SYNGR3 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
229
Applicable Applications for anti-SYNGR3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
SYNGR3 antibody can be used for detection of SYNGR3 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
Conjugate
Unconjugated
Immunogen
SYNGR3 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human SYNGR3.
Buffer
SYNGR3 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
SYNGR3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of SYNGR3 in mouse brain tissue lysate with SYNGR3 antibody at (A) 1 and (B) 2 μg/mL .)

Western Blot (WB) (Western blot analysis of SYNGR3 in mouse brain tissue lysate with SYNGR3 antibody at (A) 1 and (B) 2 μg/mL .)

Immunohistochemistry (IHC)

(Immunohistochemistry of SYNGR3 in rat brain tissue with SYNGR3 antibody at 2.5 μg/mL.)

Immunohistochemistry (IHC) (Immunohistochemistry of SYNGR3 in rat brain tissue with SYNGR3 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of SYNGR3 in Rat Brain cells with SYNGR3 antibody at 20 μg/mL.)

Immunofluorescence (IF) (Immunofluorescence of SYNGR3 in Rat Brain cells with SYNGR3 antibody at 20 μg/mL.)
Related Product Information for anti-SYNGR3 antibody
SYNGR3 Antibody: Synaptogyrins comprise a family of tyrosine-phosphorylated membrane proteins with two neuronal (SYNGR1 and SYNGR3) and one ubiquitous (SYNGR2) members. SYNGR1 and -3 are synaptic vesicle proteins, residing in some cases on the same synaptic vesicle, and are thought to be involved in the regulation of neurotransmitter release. SYNGR2, by contrast, is absent from synaptic vesicles. The role and localization of a fourth synaptogyrin, SYNGR4, is unclear. SYNGR3 is predominantly expressed in brain and placenta. SYNGR3 is involved in the positive regulation of dopamine transporter activity and facilitates the physical and functional interactions of the transporter with the dopamine vesicular storage system, allowing a more efficient loading of the vesicles with extracellular dopamine after release.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
24,555 Da
NCBI Official Full Name
synaptogyrin-3
NCBI Official Synonym Full Names
synaptogyrin 3
NCBI Official Symbol
SYNGR3
NCBI Protein Information
synaptogyrin-3
UniProt Protein Name
Synaptogyrin-3
Protein Family
UniProt Gene Name
SYNGR3
UniProt Entry Name
SNG3_HUMAN

NCBI Description

This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family. [provided by RefSeq, Dec 2010]

Uniprot Description

SYNGR3: Involved in the positive regulation of dopamine transporter activity. Probably facilitates the physical and functional interactions of the transporter with the dopamine vesicular storage system, allowing a more efficient loading of the vesicles with extracellular dopamine after release. Belongs to the synaptogyrin family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16p13

Cellular Component: synaptic vesicle; synaptic vesicle membrane; integral to membrane; cell junction; neuromuscular junction

Molecular Function: protein N-terminus binding; SH2 domain binding

Biological Process: substantia nigra development; positive regulation of transporter activity

Research Articles on SYNGR3

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Product Notes

The SYNGR3 syngr3 (Catalog #AAA151460) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SYNGR3 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SYNGR3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). SYNGR3 antibody can be used for detection of SYNGR3 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the SYNGR3 syngr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SYNGR3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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