Rabbit SYNGR1 Polyclonal Antibody | anti-SYNGR1 antibody

SYNGR1 Antibody

Cat. Num. AAA151196

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: SYNGR1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: SYNGR1; Polyclonal Antibody; SYNGR1 Antibody; Synaptogyrin-1; synaptogyrin 1; anti-SYNGR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: SYNGR1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 234

• Applicable Applications for anti-SYNGR1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: SYNGR1 antibody can be used for detection of SYNGR1 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: SYNGR1 antibody was raised against a 16 amino acid synthetic peptide from near the center of human SYNGR1.
• Buffer: SYNGR1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: SYNGR1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of SYNGR1 in rat brain tissue lysate with SYNGR1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)

Immunohistochemistry (IHC)

(Immunohistochemistry of SYNGR1 in rat brain tissue with SYNGR1 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of SYNGR1 in rat brain tissue with SYNGR1 antibody at 20 μg/mL.)

Related Product Information for anti-SYNGR1 antibody

SYNGR1 Antibody: Synaptogyrins comprise a family of tyrosine-phosphorylated membrane proteins with two neuronal (SYNGR1 and SYNGR3) and one ubiquitous (SYNGR2) members. SYNGR1 and -3 are synaptic vesicle proteins, residing in some cases on the same synaptic vesicle, and are thought to be involved in the regulation of neurotransmitter release. SYNGR2, by contrast, is absent from synaptic vesicles. The role and localization of a fourth synaptogyrin, SYNGR4, is unclear. The gene for SYNGR1is located at chromosome 22q13, a region linked to schizophrenia; however, there is mixed evidence suggesting that mutations in SYNGR1 might be associated with schizophrenia.

NCBI and Uniprot Product Information

• NCBI GI #: 2959866
• NCBI GeneID: 9145
• UniProt Accession #: O43759; O43757; O43758; Q53Y02; Q96J56; Q9UGZ4; A6NP69; A8K0E2
• Molecular Weight: 21,591 Da
• NCBI Official Full Name: synaptogyrin 1a
• NCBI Official Synonym Full Names: synaptogyrin 1
• NCBI Official Symbol: SYNGR1
• NCBI Protein Information: synaptogyrin-1
• UniProt Protein Name: Synaptogyrin-1
• Protein Family: Synaptogyrin
• UniProt Gene Name: SYNGR1
• UniProt Entry Name: SNG1_HUMAN

NCBI Description

This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

SYNGR1: Involved in the regulation of short-term and long-term synaptic plasticity. Belongs to the synaptogyrin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: synaptic vesicle membrane; melanosome; integral to membrane; neuromuscular junction; cell junction

Biological Process: regulation of long-term neuronal synaptic plasticity; regulation of short-term neuronal synaptic plasticity; protein targeting