Rabbit anti-Human Synaptotagmin-1 Polyclonal Antibody | anti-SYT antibody

Rabbit anti-human Synaptotagmin-1 polyclonal Antibody

Cat. Num. AAA1489816

• Gene Names: SYT1; P65; SYT; SVP65
• Reactivity: Human
• Applications: ELISA
• Purity: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Synonyms: Synaptotagmin-1; Polyclonal Antibody; Rabbit anti-human Synaptotagmin-1 polyclonal Antibody; Synaptotagmin I; SYT1; SVP65; anti-SYT antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Sequence Length: 422

• Applicable Applications for anti-SYT antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Non-conjugated
• Immunogen: Recombinant human Synaptotagmin-1 protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7753 / sc-12466 / sc-13993
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-SYT antibody

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca2+-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca2+-independent manner; these are neurexins, syntaxin and AP2.

NCBI and Uniprot Product Information

• NCBI GI #: 209447070
• NCBI GeneID: 6857
• NCBI Accession #: NP_001129277.1
• NCBI GenBank Nucleotide #: NM_001135805.1
• UniProt Accession #: P21579; Q6AI31
• Molecular Weight: 47,573 Da
• NCBI Official Full Name: synaptotagmin-1 isoform 1
• NCBI Official Synonym Full Names: synaptotagmin 1
• NCBI Official Symbol: SYT1
• NCBI Official Synonym Symbols: P65; SYT; SVP65
• NCBI Protein Information: synaptotagmin-1
• UniProt Protein Name: Synaptotagmin-1
• Protein Family: Synaptotagmin
• UniProt Gene Name: SYT1
• UniProt Synonym Gene Names: SVP65; SYT; SytI
• UniProt Entry Name: SYT1_HUMAN

NCBI Description

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]

Uniprot Description

SYT1: an integral membrane protein of synaptic vesicles thought to serve as a Ca(2+) sensor in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. Binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

Protein type: Membrane protein, integral; Vesicle; Calcium-binding

Chromosomal Location of Human Ortholog: 12cen-q21

Cellular Component: cell junction; excitatory synapse; integral to membrane; neuron projection; plasma membrane; presynaptic membrane; SNARE complex; synaptic vesicle; synaptic vesicle membrane; terminal button

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; calmodulin binding; clathrin binding; identical protein binding; low-density lipoprotein receptor binding; phosphatidylinositol binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein binding; protein C-terminus binding; SNARE binding; syntaxin-1 binding

Biological Process: brain development; detection of calcium ion; glutamate secretion; neurotransmitter secretion; positive regulation of calcium ion-dependent exocytosis; positive regulation of synaptic transmission; positive regulation of vesicle fusion; protein homooligomerization; regulation of exocytosis; regulation of synaptic transmission, glutamatergic; synaptic transmission; synaptic vesicle endocytosis; vesicle docking