Rabbit CXADR Polyclonal Antibody | anti-CXADR antibody

Rabbit Polyclonal to Human CXADR

Cat. Num. AAA242789

• Gene Names: CXADR; CAR; HCAR; CAR4/6
• Reactivity: Bat, Gibbon, Bovine, Chimpanzee, Guinea pig, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: CXADR; Polyclonal Antibody; Rabbit Polyclonal to Human CXADR; Anti-CXADR Antibody (Internal) IHC-plus; CAR4/6; Coxsackie-adenovirus receptor; CVB3-binding protein; CAR; HCAR; HCVADR; Human CXADR; anti-CXADR antibody

• Host: Rabbit
• Reactivity: Bat, Gibbon, Bovine, Chimpanzee, Guinea pig, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat
• Clonality: Polyclonal
• Specificity: Human CXADR. BLAST analysis of the peptide immunogen showed no homology with other human proteins. Immunogenic peptide is present in isoforms 1 and 2 per Swiss-Prot P78310.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 365

• Applicable Applications for anti-CXADR antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (10 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic 15 amino acid peptide from internal region of human CXADR. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bat, Bovine.
• Immunogen Type: Synthetic peptide
• Immunogen: CXADR antibody was raised against synthetic 15 amino acid peptide from internal region of human CXADR. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bat, Bovine, Rabbit, Horse, Pig, Opossum, Guinea pig (100%); Zebra finch, Platypus, Lizard (93%); Xenopus, Stickleback, Pufferfish, Zebrafish (80%).
• Antigen Modification: Internal
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-CXADR antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-CXADR antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-CXADR antibody

The Coxsackievirus and adenovirus receptor (CAR) is a membrane glycoprotein with a cytoplasmic domain, a transmembrane domain and an extracellular region consisting of two immunoglobulin-like domains, an amino-terminal immunoglobulin variable (IgV)-related domain (D1), which is distal to the cell surface, and a proximal IgC2 domain (D2). The Coxsackievirus and adenovirus receptor has been shown to exhibit tumor suppression activity in human bladder and prostate cancer cells.

NCBI and Uniprot Product Information

• NCBI GI #: 4503173
• NCBI GeneID: 1525
• NCBI Accession #: NP_001329.1
• NCBI GenBank Nucleotide #: NM_001338.4
• UniProt Accession #: P78310; O00694; Q8WWT6; Q8WWT7; Q8WWT8; Q9UKV4; B2R8V8; B7WPI3; D3YHP0
• Molecular Weight: 35,570 Da
• NCBI Official Full Name: coxsackievirus and adenovirus receptor isoform 1
• NCBI Official Synonym Full Names: coxsackie virus and adenovirus receptor
• NCBI Official Symbol: CXADR
• NCBI Official Synonym Symbols: CAR; HCAR; CAR4/6
• NCBI Protein Information: coxsackievirus and adenovirus receptor; HCVADR; CVB3-binding protein; coxsackievirus B-adenovirus receptor; 46 kD coxsackievirus and adenovirus receptor (CAR) protein
• UniProt Protein Name: Coxsackievirus and adenovirus receptor
• Protein Family: CXADR-like membrane protein
• UniProt Gene Name: CXADR
• UniProt Synonym Gene Names: CAR; CAR; hCAR
• UniProt Entry Name: CXAR_HUMAN

NCBI Description

The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]

Uniprot Description

CXADR: a component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1 located in the plasma membrane of PMN.

Protein type: Receptor, misc.; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 21q21.1

Cellular Component: extracellular space; neuron projection; tight junction; protein complex; basolateral plasma membrane; integral to plasma membrane; apicolateral plasma membrane; extracellular region; acrosome; intercellular junction; lipid raft; nucleoplasm; growth cone; adherens junction; plasma membrane; neuromuscular junction; cell junction; filopodium

Molecular Function: viral receptor activity; integrin binding; identical protein binding; protein binding; beta-catenin binding; cell adhesion molecule binding; PDZ domain binding; receptor binding

Biological Process: intercellular junction assembly and maintenance; neutrophil chemotaxis; mitochondrion organization and biogenesis; entry of virus into host cell; regulation of immune response; heart development; gamma-delta T cell activation; heterophilic cell adhesion; cardiac muscle fiber development; germ cell migration; homotypic cell-cell adhesion; actin cytoskeleton reorganization; blood coagulation; defense response to virus; leukocyte migration