Rabbit SUVH4 Polyclonal Antibody | anti-SUVH4 antibody

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) SUVH4 Polyclonal Antibody

• Gene Names: SUVH4; KRYPTONITE; KYP; MAC12.7; MAC12_7; SDG33; SET DOMAIN PROTEIN 33; SU(VAR)3-9 homolog 4
• Reactivity: Arabidopsis thaliana (Mouse-ear cress)
• Applications: ELISA, Western Blot
• Purity: Protein A/G
• Synonyms: SUVH4; Polyclonal Antibody; Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) SUVH4 Polyclonal Antibody; SUVH4 Antibody; Histone-lysine N-methyltransferase; H3 lysine-9 specific SUVH4; EC 2.1.1.43; Histone H3-K9 methyltransferase 4; H3-K9-HMTase 4; Protein KRYPTONITE; Protein SET DOMAIN GROUP 33; Suppressor of variegation 3-9 homolog protein 4; Su(var)3-9 homolog protein 4; SUVH4 KYP SDG33 SET33 At5g13960 MAC12.7; anti-SUVH4 antibody

• Host: Rabbit
• Reactivity: Arabidopsis thaliana (Mouse-ear cress)
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Protein A/G
• Form/Format: Liquid; Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH7.4

• Applicable Applications for anti-SUVH4 antibody: ELISA (EIA), WB (Western Blot) (ensure identification of antigen)
• Immunogen: Recombinant Arabidopsis thaliana SUVH4 protein
• Conjugation: Non-conjugate
• Modification: Unmodified
• Deliverables: 1. 200ug recombinant immunogen protein/peptide (positive control).; 2. 1mL preimmune serum (negative control); 3. 10mg rabbit polyclonal antibody purified by Protein A/G.
• Quality Guarantee: 1. Antibody purity >90% confirmed by SDS-PAGE.; 2. Antibody titer > 1: 64,000 confirmed by ELISA; 3. Western Blot positive for the immunogen protein (Not applicable for synthetic peptide).
• Complementary Antibody: Customer can choose 1 FREE antibody from the list below. Please specify the catalog # when order:; * 6*His Monoclonal Antibody #MBS1491670; * DYKDDDDK tag Monoclonal Antibody #MBS1493946; * GAPDH Monoclonal Antibody #MBS1495524; * GFP Monoclonal Antibody #MBS1496050; * Myc tag Monoclonal Antibody #MBS1497694; * GST Monoclonal Antibody #MBS1497871; * Sumo tag Monoclonal Antibody #MBS1498878; * Goat Anti-Rabbit IgG (H+L) Antibody; HRP conjugated #MBS7053510; * HA-Tag Monoclonal Antibody #MBS7135631; * E-Tag Monoclonal Antibody #MBS7135632; * TUBA1A Monoclonal Antibody #MBS7135645; * TUBB Monoclonal Antibody #MBS9018332
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

NCBI and Uniprot Product Information

• NCBI GI #: 15240758
• NCBI GeneID: 831244
• NCBI Accession #: NP_196900.1
• NCBI GenBank Nucleotide #: NM_121399.3
• UniProt Accession #: Q8GZB6; Q9C5P3; Q9FFX9
• Molecular Weight: 70,056 Da
• NCBI Official Full Name: histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein
• NCBI Official Symbol: SUVH4
• NCBI Official Synonym Symbols: KRYPTONITE; KYP; MAC12.7; MAC12_7; SDG33; SET DOMAIN PROTEIN 33; SU(VAR)3-9 homolog 4
• NCBI Protein Information: histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein
• UniProt Protein Name: Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4
• Protein Family: Histone-lysine N-methyltransferase
• UniProt Gene Name: SUVH4
• UniProt Synonym Gene Names: KYP; SDG33; SET33; H3-K9-HMTase 4; Su(var)3-9 homolog protein 4

NCBI Description

Encodes a histone 3 lysine 9 specific methyltransferase involved in the maintenance of DNA methylation. SUVH4/KYP is a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain. In kyp mutants, there is a loss of CpNpG methylation. The protein was shown to bind to methylated cytosines of CG, CNG and CNN motifs via its SRA domain but has a preference for the latter two. There is also evidence that KYP/SUVH4 might be involved in the telomerase-independent process known as Alternative Lengthening of Telomeres.

Uniprot Description

Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. The silencing mechanism via DNA CpNpG methylation requires the targeting of chromomethylase CMT3 to methylated histones, probably through an interaction with an HP1-like adapter. By its function, KYP is directly required for the maintenance of the DNA CpNpG and asymmetric methylation. Involved in the silencing of transposable elements.