Testing Data
Rabbit anti-Human Survivin Polyclonal Antibody | anti-birc5.1.S antibody
Anti-Survivin Antibody
Gene Names
birc5.1.S; Su2; BIR1; api4; svv1; XBIR1; Xsvv1; epr-1; xsurv; bir1-A; birc5.1; birc5.1-a; birc5.1-b; xSurvivin; XSurvivin1
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Purified
Synonyms
Survivin; Polyclonal Antibody; Anti-Survivin Antibody; anti-birc5.1.S antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
This IgG fraction antibody is directed against human Survivin protein. The product was purified from monospecific antiserum by selective precipitation followed by ion exchange chromatography. Reactivity against Survivin from other sources has not been determined.
Purity/Purification
Purified
Form/Format
Liquid; PBS, pH 7.4 with 0.05% sodium azide.
Concentration
1ug/ul (varies by lot)
Sequence Length
160
Applicable Applications for anti-birc5.1.S antibody
Western Blot (WB), ELISA (EIA)
Application Notes
This affinity purified antibody has been tested for use in ELISA, immunohistochemistry and western blotting. Specific conditions for reactivity should be optimized by the end user. Paraformaldehyde fixation is recommended for immunohistochemical staining. Expect a band at ~17 kDa in size corresponding to Survivin by western blotting in the appropriate cell lysate or extract.
Immunogen
This IgG fraction antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminus of human Survivin protein.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Testing Data
Testing Data
Testing Data
Testing Data
Related Product Information for anti-birc5.1.S antibody
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli, including members of the TNF family, and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated Survivin (also referred to as apoptosis inhibitor 4 (API4) and TIAP). Survivin interacts with the processed form of caspase-3 and inhibits its proteolytic activity. Survivin is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
survivin
NCBI Official Synonym Full Names
baculoviral IAP repeat-containing 5, gene 1 S homeolog
NCBI Official Symbol
birc5.1.S
NCBI Official Synonym Symbols
Su2; BIR1; api4; svv1; XBIR1; Xsvv1; epr-1; xsurv; bir1-A; birc5.1; birc5.1-a; birc5.1-b; xSurvivin; XSurvivin1
NCBI Protein Information
baculoviral IAP repeat-containing protein 5.1-A
UniProt Protein Name
Baculoviral IAP repeat-containing protein 5.1-A
UniProt Gene Name
birc5.1-a
UniProt Synonym Gene Names
bir1-AImportedManual assertion inferred from database entriesiEMBL:AAH73047.1; svv11 PublicationManual assertion based on opinion iniRef.3; XBIR11 PublicationManual assertion based on opinion iniRef.1; XSurvivin11 PublicationManual assertion based on opin
Uniprot Description
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Stimulates the mitotic kinase activity of aurkb/aurora-B in the CPC. Does not appear to exhibit anti-apoptotic activity.
Research Articles on birc5.1.S
Similar Products
Product Notes
The birc5.1.S birc5.1-a (Catalog #AAA4157001) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Survivin Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Survivin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). This affinity purified antibody has been tested for use in ELISA, immunohistochemistry and western blotting. Specific conditions for reactivity should be optimized by the end user. Paraformaldehyde fixation is recommended for immunohistochemical staining. Expect a band at ~17 kDa in size corresponding to Survivin by western blotting in the appropriate cell lysate or extract. Researchers should empirically determine the suitability of the birc5.1.S birc5.1-a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Survivin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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