Rabbit anti-Human, Mouse BIRC5 / Survivin Polyclonal Antibody | anti-BIRC5 antibody

Rabbit Polyclonal to Human BIRC5 / Survivin

Cat. Num. AAA248725

• Gene Names: BIRC5; API4; EPR-1
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Affinity Purified
• Synonyms: BIRC5 / Survivin; Polyclonal Antibody; Rabbit Polyclonal to Human BIRC5 / Survivin; Anti-BIRC5 / Survivin Antibody IHC-plus; BIRC5; API4; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; Survivin; Survivin variant 3 alpha; EPR-1; IAP4; Human BIRC5; anti-BIRC5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: c-terminal
• Purity/Purification: Affinity Purified
• Form/Format: 10mM PBS, pH 7.6, with 0.2% BSA and 15mM sodium azide
• Concentration: 0.2 mg/ml (varies by lot)
• Sequence Length: 142

• Applicable Applications for anti-BIRC5 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (10 ug/ml)
• Target Species: Human
• Immunogen Description: A synthetic peptide derived from the C-terminus of human survivin.
• Immunogen Type: Synthetic peptide
• Immunogen: BIRC5 / Survivin antibody was raised against a synthetic peptide derived from the C-terminus of human survivin.
• Preparation and Storage: Stable for 24 months when stored at 2-8 degree C.

Immunohistochemistry (IHC)

(Anti-BIRC5 / Survivin antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Formalin-fixed, paraffin-embedded human pancreas stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of islet cells.)

Related Product Information for anti-BIRC5 antibody

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP.

Product Categories/Family for anti-BIRC5 antibody

Family: Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 59859878
• NCBI GeneID: 332
• NCBI Accession #: NP_001159.2
• NCBI GenBank Nucleotide #: NM_001168.2
• UniProt Accession #: O15392; Q2I3N8; Q4VGX0; Q53F61; Q5MGC6; Q6FHL2; Q75SP2; Q9P2W8; A2SUH6; B2R4R1
• Molecular Weight: 8,490 Da
• NCBI Official Full Name: baculoviral IAP repeat-containing protein 5 isoform 1
• NCBI Official Synonym Full Names: baculoviral IAP repeat containing 5
• NCBI Official Symbol: BIRC5
• NCBI Official Synonym Symbols: API4; EPR-1
• NCBI Protein Information: baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin variant 3 alpha; apoptosis inhibitor survivin
• UniProt Protein Name: Baculoviral IAP repeat-containing protein 5
• Protein Family: Baculoviral IAP repeat-containing protein
• UniProt Gene Name: BIRC5
• UniProt Synonym Gene Names: API4; IAP4
• UniProt Entry Name: BIRC5_HUMAN

NCBI Description

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Uniprot Description

Survivin: an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: centriole; nuclear chromosome; microtubule; spindle microtubule; cytoplasmic microtubule; cytoplasm; spindle; midbody; interphase microtubule organizing center; nucleus; cytosol; chromosome, pericentric region

Molecular Function: tubulin binding; identical protein binding; protein homodimerization activity; zinc ion binding; microtubule binding; metal ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; protein binding; enzyme binding; protein heterodimerization activity; chaperone binding; cofactor binding; cysteine protease inhibitor activity; Ran GTPase binding; cobalt ion binding

Biological Process: mitosis; spindle checkpoint; transcription, DNA-dependent; establishment of chromosome localization; protein ubiquitination; regulation of signal transduction; cytokinesis; negative regulation of caspase activity; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; chromosome segregation; protein complex localization; cell division; positive regulation of cell proliferation; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent; positive regulation of exit from mitosis; negative regulation of apoptosis