Western Blot (WB)
(Western blot analysis of Sugen Kinase 269 expression in SHSY5Y (A), NIH3T3 (B) whole cell lysates.)
Rabbit anti-Human, Mouse Sugen Kinase 269 Polyclonal Antibody | anti-PEAK1 antibody
Anti-Sugen Kinase 269 Antibody
Western Blot (WB)
(Western blot analysis of Sugen Kinase 269 expression in SHSY5Y (A), NIH3T3 (B) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of Sugen Kinase 269 expression in SHSY5Y (A), NIH3T3 (B) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]
Uniprot Description
PEAK1: a cytoskeleton-associated non-receptor tyrosine kinase that localizes to focal adhesions and actin filaments. Operates downstream of integrin and epidermal growth factor receptors, regulating the P130Cas-Crk-PXN and MAPK signaling. In the late stages of EGF signaling, SGK269 mediates Shc1 protein interactions involved in and cell spreading, migration, and morphogenesis. Amplified in a large fraction of colon cancer. Influences anchorage-independent growth and tumor progression in mice.
Protein type: EC 2.7.10.2; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Other group; NKF3 family
Chromosomal Location of Human Ortholog: 15q24.3
Cellular Component: actin cytoskeleton; cytoplasm; focal adhesion; nucleoplasm; plasma membrane
Molecular Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; protein binding
Biological Process: cell migration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation
Research Articles on PEAK1
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Product Notes
The PEAK1 peak1 (Catalog #AAA8242124) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Sugen Kinase 269 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Sugen Kinase 269 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: (1/500 - 1/1000). Researchers should empirically determine the suitability of the PEAK1 peak1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sugen Kinase 269, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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