Rabbit anti-Human STK38 Polyclonal Antibody | anti-STK38 antibody

STK38, CT (Serine/Threonine-protein Kinase 38, NDR1 Protein Kinase, Nuclear Dbf2-related Kinase 1, STK38, NDR1) (FITC)

Cat. Num. AAA6501224

• Gene Names: STK38; NDR; NDR1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein G Affinity Chromatography.
• Synonyms: STK38; Polyclonal Antibody; CT (Serine/Threonine-protein Kinase 38; NDR1 Protein Kinase; Nuclear Dbf2-related Kinase 1; NDR1) (FITC); anti-STK38 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human STK38.
• Purity/Purification: Purified by Protein G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-STK38 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:250-1:500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the C-terminal region of human STK38 (KLH).
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(The anti-STK38 Pab is used in Western blot to detect STK38 in SK-Br-3 (left) and Jurkat (right) cell line lysates.)

Product Categories/Family for anti-STK38 antibody

Antibodies; Protein Kinases

References

1. Devroe, E., et al., J. Biol. Chem. 279(23):24444-24451 (2004). 2. Tamaskovic, R., et al., J. Biol. Chem. 278(9):6710-6718 (2003). 3. Tripodis, N., et al., Genome Res. 8(6):631-643 (1998). 4. Millward, T., et al., Proc. Natl. Acad. Sci. USA 92(11):5022-5026 (1995).

NCBI and Uniprot Product Information

• NCBI GI #: 6005814
• NCBI GeneID: 11329
• NCBI Accession #: NP_009202
• NCBI GenBank Nucleotide #: NM_007271
• UniProt Accession #: Q15208; Q503A1
• Molecular Weight: 54,190 Da
• NCBI Official Full Name: serine/threonine-protein kinase 38
• NCBI Official Synonym Full Names: serine/threonine kinase 38
• NCBI Official Symbol: STK38
• NCBI Official Synonym Symbols: NDR; NDR1
• NCBI Protein Information: serine/threonine-protein kinase 38; NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1
• UniProt Protein Name: Serine/threonine-protein kinase 38
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: STK38
• UniProt Entry Name: STK38_HUMAN

Uniprot Description

NDR1: is an AGC kinase of the NDR family. An apparent upstream regulator of Myc activity in human B-cell lymphoma. Mediates apoptosis downstream of the tumor suppressor proteins RASSF1A and MST1. Reduced expression of NDR1 results in defective apoptotic responses and a predisposition to develop T cell lymphoma in mice. Activated by binding of S100B which releases autoinhibitory N-lobe interactions. Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, AGC; AGC group; NDR family

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; ATP binding

Biological Process: negative regulation of MAP kinase activity; protein modification process; protein amino acid phosphorylation