Western Blot analysis of HepG2 cells using Phospho-ERb (S105) Polyclonal antibody.
Rabbit ERbeta Polyclonal Antibody | anti-ERbeta antibody
ERbeta (phospho Ser105) Polyclonal Antibody
Immunofluorescence (IF) 1/200-1/1000
ELISA (EIA)1/5000.
Not yet tested in other applications.
Western Blot analysis of HepG2 cells using Phospho-ERb (S105) Polyclonal antibody.
Western Blot analysis of HepG2 cells using Phospho-ERb (S105) Polyclonal antibody.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
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Product Notes
The ERbeta esr2 (Catalog #AAA8520327) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ERbeta (phospho Ser105) Polyclonal Antibody reacts with Human, Mouse, Rat. and may cross-react with other species as described in the data sheet. AAA Biotech's ERbeta can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF), ELISA (EIA). Western Blot (WB) 1/500-1/2000 Immunofluorescence (IF) 1/200-1/1000 ELISA (EIA)1/5000. Not yet tested in other applications. Researchers should empirically determine the suitability of the ERbeta esr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERbeta, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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