Rabbit anti-Human STARD5 Polyclonal Antibody | anti-STARD5 antibody

STARD5 Antibody

Cat. Num. AAA9403237

• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: STARD5; Polyclonal Antibody; STARD5 Antibody; anti-STARD5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total STARD5 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 2.4 mg/ml (varies by lot)
• Sequence Length: 213

• Applicable Applications for anti-STARD5 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500-1:2000; Immunohistochemistry: 1:40-1:150
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the N terminal of human StAR-related lipid transfer (START) domain containing 5
• Target Name: STARD5
• Preparation and Storage: Store at -20 degree C

Testing Data

(Gel: 12%SDS-PAGE Lysate: 40ug Human fetal brain tissuePrimary antibody: 1/400 dilution Secondary antibody dilution: 1/8000Exposure time: 2 minutes)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/40.)

Related Product Information for anti-STARD5 antibody

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake.

Product Categories/Family for anti-STARD5 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 32526915
• NCBI GeneID: 80765
• NCBI Accession #: NP_871629.1
• NCBI GenBank Nucleotide #: NM_181900.2
• UniProt Accession #: Q9NSY2; P59094
• Molecular Weight: 7,094 Da
• NCBI Official Full Name: stAR-related lipid transfer protein 5
• NCBI Official Synonym Full Names: StAR-related lipid transfer (START) domain containing 5
• NCBI Official Symbol: STARD5
• NCBI Protein Information: stAR-related lipid transfer protein 5
• UniProt Protein Name: StAR-related lipid transfer protein 5
• Protein Family: StAR-related lipid transfer protein
• UniProt Gene Name: STARD5
• UniProt Synonym Gene Names: StARD5
• UniProt Entry Name: STAR5_HUMAN

NCBI Description

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]

Uniprot Description

STARD5: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 15q26

Cellular Component: cytosol

Molecular Function: bile acid binding

Biological Process: steroid metabolic process; C21-steroid hormone biosynthetic process; lipid transport