Rabbit SRPX2 Polyclonal Antibody | anti-SRPX2 antibody

Rabbit Polyclonal to Human SRPX2

Cat. Num. AAA247249

• Gene Names: SRPX2; BPP; CBPS; PMGX; RESDX; SRPUL
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: SRPX2; Polyclonal Antibody; Rabbit Polyclonal to Human SRPX2; Anti-SRPX2 Antibody (N-Terminus) IHC-plus; BPP; CBPS; PMGX; RESDX; SRPUL; Human SRPX2; anti-SRPX2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Human SRPX2
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 465

• Applicable Applications for anti-SRPX2 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml); Usage: SRPX2 antibody can be used for detection of SRPX2 by Western blot at 1-2 ug/ml.
• Target Species: Human
• Immunogen Description: A 16 amino acid peptide from near the amino terminus of human SRPX2.
• Immunogen Type: Synthetic peptide
• Immunogen: SRPX2 antibody was raised against a 16 amino acid peptide from near the amino terminus of human SRPX2.
• Antigen Modification: N-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-SRPX2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-SRPX2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of SRPX2 in human lung tissue with SRPX2 antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot of SRPX2 in human lung tissue lysate with SRPX2 antibody at (A) 1 and (B) 2 ug/ml.)

Related Product Information for anti-SRPX2 antibody

Sushi repeat-containing protein/sushi-repeat protein upregulated in leukemia may have a role in the pathogenesis of retinitis pigmentosa and has been shown to be up regulated in the pro-B leukemia cell line UDC-81.

NCBI and Uniprot Product Information

• NCBI GI #: 7657619
• NCBI GeneID: 27286
• NCBI Accession #: NP_055282.1
• NCBI GenBank Nucleotide #: NM_014467.2
• UniProt Accession #: O60687; Q8WW85; B3KQT3
• Molecular Weight: 52,972 Da
• NCBI Official Full Name: sushi repeat-containing protein SRPX2
• NCBI Official Synonym Full Names: sushi-repeat containing protein, X-linked 2
• NCBI Official Symbol: SRPX2
• NCBI Official Synonym Symbols: BPP; CBPS; PMGX; RESDX; SRPUL
• NCBI Protein Information: sushi repeat-containing protein SRPX2; sushi-repeat-containing protein, X-linked 2; sushi-repeat protein upregulated in leukemia; sushi-repeat protein up-regulated in leukemia
• UniProt Protein Name: Sushi repeat-containing protein SRPX2
• Protein Family: Sushi repeat-containing protein
• UniProt Gene Name: SRPX2
• UniProt Synonym Gene Names: SRPUL
• UniProt Entry Name: SRPX2_HUMAN

NCBI Description

This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and mental retardation. [provided by RefSeq, May 2010]

Uniprot Description

SRPX2: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion in cancer cells. Increases the phosphorylation levels of FAK. May have a role in the perisylvian region, critical for language and cognitive development. Defects in SRPX2 are a cause of bilateral perisylvian polymicrogyria (BPP). BPP is the most common form of polymicrogyria, a malformation of the cortex, in which the brain surface is irregular and the normal gyral pattern replaced by multiple small, partly fused, gyri separated by shallow sulci. BPP results in mild mental retardation, epilepsy and pseudobulbar palsy, causing difficulties with expressive speech and feeding. Defects in SRPX2 are a cause of rolandic epilepsy with speech dyspraxia and mental retardation X-linked (RESDX). A condition characterized by the association of rolandic seizures with oral and speech dyspraxia, and mental retardation. Rolandic occur during a period of significant brain maturation. During this time, dysfunction of neural network activities such as focal discharges may be associated with specific developmental disabilities resulting in specific cognitive impairments of language, visuo-spatial abilities or attention.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xq22.1

Cellular Component: extracellular space; cell surface; cytoplasm; excitatory synapse; cell junction

Molecular Function: identical protein binding; protein binding; receptor binding

Biological Process: positive regulation of synaptogenesis; cell-cell adhesion; regulation of phosphorylation; cell motility involved in cell locomotion; angiogenesis

Disease: Rolandic Epilepsy, Mental Retardation, And Speech Dyspraxia, X-linked