Rabbit anti-Human SRBC Polyclonal Antibody | anti-SRBC antibody

SRBC, ID (Protein Kinase C delta-binding Protein, Cavin-3, Serum Deprivation Response Factor-related Gene Product That Binds to C-kinase, hSRBC, PRKCDBP) (MaxLight 550)

Cat. Num. AAA6499117

• Gene Names: PRKCDBP; SRBC; HSRBC; CAVIN3; cavin-3
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Ammonium Sulfate Precipitation.
• Synonyms: SRBC; Polyclonal Antibody; ID (Protein Kinase C delta-binding Protein; Cavin-3; Serum Deprivation Response Factor-related Gene Product That Binds to C-kinase; hSRBC; PRKCDBP) (MaxLight 550); anti-SRBC antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PRKCDBP.
• Purity/Purification: Purified by Ammonium Sulfate Precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

• Applicable Applications for anti-SRBC antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:50-1:100; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the center region of human PRKCDBP (KLH).
• Conjugate: MaxLight550
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-PRKCDBP Antibody (Center) in A2058 cell line lysates (35ug/lane). PRKCDBP (arrow) was detected using the purified Pab.)

Western Blot (WB)

(Western blot analysis of PRKCDBP (arrow) using rabbit polyclonal PRKCDBP Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PRKCDBP gene (Lane 2) (Origene Technologies).)

Product Categories/Family for anti-SRBC antibody

Antibodies; Protein Kinases

References

1. Lee, J.H., Int. J. Cancer 122(7), 1573-1584 (2008). 2. Zochbauer-Muller, S., Oncogene 24(41), 6249-6255 (2005). 3. Xu, X.L., Cancer Res. 61(21), 7943-7949 (2001).

NCBI and Uniprot Product Information

• NCBI GI #: 47132587
• NCBI GeneID: 112464
• NCBI Accession #: NP_659477
• NCBI GenBank Nucleotide #: NM_145040.2
• UniProt Accession #: Q969G5
• Molecular Weight: 29 kDa
• NCBI Official Full Name: protein kinase C delta-binding protein
• NCBI Official Synonym Full Names: protein kinase C, delta binding protein
• NCBI Official Symbol: PRKCDBP
• NCBI Official Synonym Symbols: SRBC; HSRBC; CAVIN3; cavin-3
• NCBI Protein Information: protein kinase C delta-binding protein; sdr-related gene product that binds to c-kinase; serum deprivation response factor-related gene product that binds to C-kinase
• UniProt Protein Name: Protein kinase C delta-binding protein
• UniProt Gene Name: PRKCDBP
• UniProt Synonym Gene Names: SRBC; hSRBC
• UniProt Entry Name: PRDBP_HUMAN

NCBI Description

The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]

Uniprot Description

PRKCDBP: Seems to have an immune potentiation function. Belongs to the PTRF/SDPR family.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: protein complex; cytoplasm; caveola

Molecular Function: protein binding; protein kinase C binding

Biological Process: negative regulation of protein kinase B signaling cascade; cortical actin cytoskeleton organization and biogenesis; circadian regulation of gene expression