Western Blot (WB)
(SPO11 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SPO11 antibody detected the SPO11 protein (arrow).)
Rabbit anti-Human SPO11 Polyclonal Antibody | anti-SPO11 antibody
SPO11 Antibody (C-term)
Western Blot (WB)
(SPO11 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SPO11 antibody detected the SPO11 protein (arrow).)
Western Blot (WB)
(SPO11 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SPO11 antibody detected the SPO11 protein (arrow).)
the formation of double-strand breaks (DSBs) in paired chromosome
homologs. During meiosis in yeast, a meiotic recombination protein
is covalently-linked to the 5' end of DSBs and is essential for the
formation of DSBs. The protein encoded by this gene is similar in
sequence and conserved features to the yeast meiotic recombination
protein. The encoded protein belongs to the TOP6A protein family.
Several transcript variants encoding different isoforms have been
found for this gene, but the full-length nature of only two of them
have been described.
Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Mandon-Pepin, B., et al. Eur. J. Endocrinol. 158(1):107-115(2008)
Christensen, G.L., et al. Fertil. Steril. 84(3):758-760(2005)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
NCBI and Uniprot Product Information
NCBI Description
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
SPO11: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. Belongs to the TOP6A family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Cell cycle regulation; Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 20q13.31
Cellular Component: chromosome, telomeric region; nucleus
Molecular Function: DNA binding; hydrolase activity; ATP binding
Biological Process: ovarian follicle development; male meiosis I; meiotic recombination; synapsis; female gamete generation; spermatogenesis; DNA catabolic process, endonucleolytic; spermatid development
Research Articles on SPO11
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Product Notes
The SPO11 spo11 (Catalog #AAA9210066) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 299-326. The SPO11 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SPO11 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SPO11 spo11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPO11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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