Western Blot (WB)
(Western blot analysis of Jurkat cell lysate (lane 1 & 2) probed with Rabbit anti SOCS-1 antibody)
Rabbit anti-Rat SOCS-1 Polyclonal Antibody | anti-SOCS-1 antibody
RABBIT ANTI SOCS-1
Shelf Life: 12 months from date of despatch
Western Blot (WB)
(Western blot analysis of Jurkat cell lysate (lane 1 & 2) probed with Rabbit anti SOCS-1 antibody)
Western Blot (WB)
(Western blot analysis of Jurkat cell lysate (lane 1 & 2) probed with Rabbit anti SOCS-1 antibody)
NCBI and Uniprot Product Information
NCBI Description
suppressor of cytokine signalling [RGD, Feb 2006]
Uniprot Description
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (). SOCS1 appears to be a negative regulator in IGF1R signaling pathway ().
Research Articles on SOCS-1
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Product Notes
The SOCS-1 socs1 (Catalog #AAA224931) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RABBIT ANTI SOCS-1 reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SOCS-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 0.5; 4.0 ug/ml. Researchers should empirically determine the suitability of the SOCS-1 socs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SOCS-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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