Immunohistochemistry (IHC)-Paraffin
(Formalin-fixed and paraffin-embedded human brain tissue reacted with SNRPC Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Rabbit anti-Human SNRPC Polyclonal Antibody | anti-SNRPC antibody
SNRPC Antibody (C-term)
WB: 1:1000
FC/FACS: 1:10-50
Immunohistochemistry (IHC)-Paraffin
(Formalin-fixed and paraffin-embedded human brain tissue reacted with SNRPC Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)-Paraffin
(Formalin-fixed and paraffin-embedded human brain tissue reacted with SNRPC Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Western Blot (WB)
(All lanes : Anti-SNRPC Antibody (C-term) at 1:1000 dilutionLane 1: K562 whole cell lysateLane 2: Hela whole cell lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 17 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Western Blot (WB)
(All lanes : Anti-SNRPC Antibody (C-term) at 1:1000 dilutionLane 1: K562 whole cell lysateLane 2: Hela whole cell lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 17 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Flow Cytometry (FC/FACS)
(SNRPC Antibody (C-term) flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(SNRPC Antibody (C-term) flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Background: SNRPC is associated with snRNP U1.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.[provided by RefSeq, Oct 2009]
Uniprot Description
snRNP C: Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 small nuclear ribonucleoprotein C family.
Protein type: RNA splicing; Spliceosome; RNA-binding
Chromosomal Location of Human Ortholog: 6p21.31
Cellular Component: nucleoplasm; Cajal body; snRNP U1
Molecular Function: mRNA binding; protein binding; single-stranded RNA binding; protein homodimerization activity; U1 snRNA binding; zinc ion binding
Biological Process: nuclear mRNA splicing, via spliceosome; nuclear mRNA 5'-splice site recognition; spliceosomal snRNP biogenesis
Research Articles on SNRPC
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Product Notes
The SNRPC snrpc (Catalog #AAA9232085) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SNRPC Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SNRPC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Flow Cytometry (FC/FACS), ELISA (EIA). IHC-P: 1:50-100 WB: 1:1000 FC/FACS: 1:10-50. Researchers should empirically determine the suitability of the SNRPC snrpc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNRPC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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