Rabbit SLITRK1 Polyclonal Antibody | anti-SLITRK1 antibody

Rabbit Polyclonal to Human SLITRK1

Cat. Num. AAA242595

• Gene Names: SLITRK1; TTM; LRRC12
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: SLITRK1; Polyclonal Antibody; Rabbit Polyclonal to Human SLITRK1; Anti-SLITRK1 Antibody (C-Terminus) IHC-plus; LRRC12; KIAA1910; RP11-395N17.1; SLIT and NTRK-like protein 1; Slit and trk like gene 1; TTM; Human SLITRK1; anti-SLITRK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 696

• Applicable Applications for anti-SLITRK1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: 16 amino acid peptide from near the carboxy terminus of human Slitrk1.
• Immunogen: SLITRK1 antibody was raised against 16 amino acid peptide from near the carboxy terminus of human Slitrk1.
• Antigen Modification: C-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-SLITRK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-SLITRK1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of slitrk1 in human brain tissue with slitrk1 antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot of Slitrk1 in human brain tissue lysate with Slitrk1 antibody at (A) 1 and (B) 2 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 40217817
• NCBI GeneID: 114798
• NCBI Accession #: NP_443142.1
• NCBI GenBank Nucleotide #: NM_052910.2
• UniProt Accession #: Q96PX8; Q5U5I6; Q96SF9
• Molecular Weight: 77,735 Da
• NCBI Official Full Name: SLIT and NTRK-like protein 1
• NCBI Official Synonym Full Names: SLIT and NTRK-like family, member 1
• NCBI Official Symbol: SLITRK1
• NCBI Official Synonym Symbols: TTM; LRRC12
• NCBI Protein Information: SLIT and NTRK-like protein 1; slit and trk like gene 1; leucine-rich repeat-containing protein 12
• UniProt Protein Name: SLIT and NTRK-like protein 1
• Protein Family: SLIT and NTRK-like protein
• UniProt Gene Name: SLITRK1
• UniProt Synonym Gene Names: KIAA1910; LRRC12
• UniProt Entry Name: SLIK1_HUMAN

NCBI Description

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

SLITRK1: Enhances neuronal dendrite outgrowth. Defects in SLITRK1 may be a cause of Gilles de la Tourette syndrome (GTS). GTS is a neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. Defects in SLITRK1 may be a cause of trichotillomania (TTM). It is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder. Belongs to the SLITRK family.

Protein type: Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q31.1

Cellular Component: integral to membrane

Biological Process: homeostatic process; axonogenesis; multicellular organism growth; adult behavior

Disease: Gilles De La Tourette Syndrome; Trichotillomania