Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of Cav3.1 Calcium Channel protein using Mouse Anti-Cav3.1 Calcium Channel Monoclonal Antibody, Clone S178A-9. Primary Antibody: Mouse Anti-Cav3.1 Calcium Channel Monoclonal Antibody at 1:1000.)
Mouse CaV3.1 Monoclonal Antibody | anti-Cacna1g antibody
CaV3.1 Antibody: Biotin
Gene Names
Cacna1g; a1G; [a]1G; Cav3.1d; alpha-1G; mKIAA1123
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Synonyms
CaV3.1; Monoclonal Antibody; CaV3.1 Antibody: Biotin; CACNA1G; CaV T1; Cav3 1; cav3 1c; KIAA1123; MGC117234; NBR13; voltage gated calcium channel cav3.1; calcium channel voltage dependent alpha 1G subunit; calcium channel voltage dependent T type alpha 1G subunit; calcium channel antibody; anti-Cacna1g antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
S178A-9
Form/Format
Protein G Purified
Concentration
1mg/mL (varies by lot)
Sequence Length
2272
Applicable Applications for anti-Cacna1g antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
1:1000 (WB)
Conjugate
Biotin
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Preparation and Storage
-20 degree C
Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of Cav3.1 Calcium Channel protein using Mouse Anti-Cav3.1 Calcium Channel Monoclonal Antibody, Clone S178A-9. Primary Antibody: Mouse Anti-Cav3.1 Calcium Channel Monoclonal Antibody at 1:1000.)
Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of Cav3.1 Calcium Channel protein using Mouse Anti-Cav3.1 Calcium Channel Monoclonal Antibody, Clone S178A-9. Primary Antibody: Mouse Anti-Cav3.1 Calcium Channel Monoclonal Antibody at 1:1000.)
Related Product Information for anti-Cacna1g antibody
Background Info: Detects ~>200kDa. Does not cross-react with Cav3.2
Scientific Background: Calcium channel CaV3.1 (a1G) is a low-voltage-activated T-type calcium channel. Such T-type channels are expressed throughout the body. In the heart, they may be involved in pacemaker current. In neurons, these channels may play a secondary pacemaker role (3). With the ubiquitous expression, it is not surprising that alterations in channel function have been implicated in disease. Drugs that act to block T-type calcium channels are used as anti-hypertensives, antiepileptic's, and blocking of T-type calcium channels may be involved in the action of some anesthetics and antipsychotics as well (3). Much remains to be determined about the precise cellular localization, in vivo physiological roles, roles in disease states and possible routes to modulate their structure/function to ameliorate effects of disease.
Scientific Background: Calcium channel CaV3.1 (a1G) is a low-voltage-activated T-type calcium channel. Such T-type channels are expressed throughout the body. In the heart, they may be involved in pacemaker current. In neurons, these channels may play a secondary pacemaker role (3). With the ubiquitous expression, it is not surprising that alterations in channel function have been implicated in disease. Drugs that act to block T-type calcium channels are used as anti-hypertensives, antiepileptic's, and blocking of T-type calcium channels may be involved in the action of some anesthetics and antipsychotics as well (3). Much remains to be determined about the precise cellular localization, in vivo physiological roles, roles in disease states and possible routes to modulate their structure/function to ameliorate effects of disease.
Product Categories/Family for anti-Cacna1g antibody
References
1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.:Sunderland, MA USA. 2. www.iochannels.org 3. Perez-Reyes E. (2003). Physiol. Rev., 83: 117-161.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
253,960 Da
NCBI Official Full Name
calcium channel, voltage-dependent, T type, alpha 1G subunit isoform b
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, T type, alpha 1G subunit
NCBI Official Symbol
Cacna1g
NCBI Official Synonym Symbols
a1G; [a]1G; Cav3.1d; alpha-1G; mKIAA1123
NCBI Protein Information
calcium channel, voltage-dependent, T type, alpha 1G subunit
UniProt Protein Name
Voltage-gated calcium channel, alpha-1-G subunit
Protein Family
UniProt Gene Name
Cacna1g
UniProt Entry Name
Q9WUT2_MOUSE
Uniprot Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Research Articles on Cacna1g
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Product Notes
The Cacna1g cacna1g (Catalog #AAA801815) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CaV3.1 Antibody: Biotin reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CaV3.1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). 1:1000 (WB). Researchers should empirically determine the suitability of the Cacna1g cacna1g for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CaV3.1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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