Western Blot (WB)
Rabbit anti-Mouse, Rat SLC7A10 Polyclonal Antibody | anti-SLC7A10 antibody
SLC7A10 Antibody
Gene Names
SLC7A10; ASC1; asc-1; HASC-1
Reactivity
Mouse, Rat
Applications
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Synonyms
SLC7A10; Polyclonal Antibody; SLC7A10 Antibody; AAA1_HUMAN antibody; ASC-1 antibody; Asc-type amino acid transporter 1 antibody; D-serine transporter antibody; HASC 1 antibody; Slc7a10 antibody; Solute carrier family 7 member 10 antibody; solute carrier family 7; (neutral amino acid transporter; y+ system) member 10 antibody; anti-SLC7A10 antibody
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Form/Format
Affinity Purified Immunoglobulins
Sequence Length
523
Applicable Applications for anti-SLC7A10 antibody
Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes
Confocal Microscopy: 1:50
Dot Blot: 1:4,000
ELISA: 1:4,000
Immunocytochemistry: 1:50
Immunofluorescence: 1:50
Immunohistochemistry: 1:50
Immunoprecipitation: 1:200
Western Blot: 1:500-1:1,000
Dot Blot: 1:4,000
ELISA: 1:4,000
Immunocytochemistry: 1:50
Immunofluorescence: 1:50
Immunohistochemistry: 1:50
Immunoprecipitation: 1:200
Western Blot: 1:500-1:1,000
Immunogen
Synthetic peptide taken within amino acid region 1-50 on rat Asc-type amino acid transporter 1 protein.
Determinant
N-epitope
Structure
Disulfide-linked heterodimer.
Immunoglobulin & Concentration
0.75 mg/mL IgG in antibody stabilization buffer
Preparation and Storage
Store at -20°C for long term storage.
Western Blot (WB)
Western Blot (WB)
Related Product Information for anti-SLC7A10 antibody
Amino acid transport across the plasma membrane is mediated by both sodium-dependetn and sodium independent transport mechanism (1). It has been shown that sodium-independent amino acid transporter covalently interact with the heavy chain of a cell surface antigen 4F2 also known as CD98. Structurally 4F2 compose of a 4F2 heavy chain (4F2hc) is an integral membrane protein and a light chain that has intrinsic amino acid transport properties. Various amino acid transporters including transport type L, y + L and xc- has been shown to be the 2F4 light chains and assemble with 2F4hc for their functional amino acid transport activities (3,4). Recently a protein structurally related to amino acid transporter, with a characteristic 12 transmembrane domains has been cloned mouse brain that associates with 2F4hc for its small neutral amino acid transport activity (1). This transporter belongs to the LAT2 family, a component for system L transporter. The ASC-1 showed 65% identity to LAT2, 45% to LAT1,Y +LAT1 and KIAA0245/y+LAT2 type transporters(5). The transporter ASC-1 is a member of the solute carrier family 7 and serves as a cationic amino acid transporter (y+ system). The ASC-1 protein has 530 amino acids (MW 63-64 kDa) is expressed in brain, lungs and intestine. It has two consensus phosphorylation sites (PKA and PKC) that are conserved in all y+ transport system. ASC1 tranporter also transports with high affinity D and L- amino acid related compounds and may involvein glutaminergic transmission in brain by modulating D-serine at glutaminergic synapse. ASC-1 forms disulfide dimmers with ASC transporter and SLC3A2/4F2hc proteins.
The ASC-1 selective antibodies was generated against C-terminal peptides that are unique to ASC-1 protein. These antibodies have been fully characterized for cross reactivity with other members of the amino acid transporter system/
The ASC-1 selective antibodies was generated against C-terminal peptides that are unique to ASC-1 protein. These antibodies have been fully characterized for cross reactivity with other members of the amino acid transporter system/
Product Categories/Family for anti-SLC7A10 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Asc-type amino acid transporter 1
NCBI Official Synonym Full Names
solute carrier family 7 member 10
NCBI Official Symbol
SLC7A10
NCBI Official Synonym Symbols
ASC1; asc-1; HASC-1
NCBI Protein Information
asc-type amino acid transporter 1
UniProt Protein Name
Asc-type amino acid transporter 1
Protein Family
UniProt Gene Name
SLC7A10
UniProt Synonym Gene Names
ASC1; Asc-1
UniProt Entry Name
AAA1_HUMAN
NCBI Description
SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]).[supplied by OMIM, Mar 2008]
Uniprot Description
SLC7A10: Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse. Belongs to the amino acid-polyamine-organocation (APC) superfamily.
Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Transporter
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: dendrite; integral to plasma membrane; membrane; plasma membrane
Molecular Function: antiporter activity; L-serine transmembrane transporter activity; neutral amino acid transmembrane transporter activity
Biological Process: amino acid transport; D-alanine transport; D-serine transport; L-serine transport; leukocyte migration; neutral amino acid transport
Research Articles on SLC7A10
Similar Products
Product Notes
The SLC7A10 slc7a10 (Catalog #AAA540604) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLC7A10 Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SLC7A10 can be used in a range of immunoassay formats including, but not limited to, Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). Confocal Microscopy: 1:50 Dot Blot: 1:4,000 ELISA: 1:4,000 Immunocytochemistry: 1:50 Immunofluorescence: 1:50 Immunohistochemistry: 1:50 Immunoprecipitation: 1:200 Western Blot: 1:500-1:1,000. Researchers should empirically determine the suitability of the SLC7A10 slc7a10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC7A10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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