Rabbit SLC22A5 Polyclonal Antibody | anti-SLC22A5 antibody

SLC22A5 Antibody

Cat. Num. AAA9408177

• Gene Names: SLC22A5; CDSP; OCTN2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: SLC22A5; Polyclonal Antibody; SLC22A5 Antibody; CDSP; FLJ46769; OCTN2; OCTN2VT; anti-SLC22A5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total SLC22A5 protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 581

• Applicable Applications for anti-SLC22A5 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunohistochemistry: 1:50 - 1:100; Immunofluorescence: 1:50 - 1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human SLC22A5.
• Target Name: SLC22A5
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using SLC22A5 antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of MCF7 cell using SLC22A5 antibody. Blue: DAPI for nuclear staining.)

Related Product Information for anti-SLC22A5 antibody

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy.

Product Categories/Family for anti-SLC22A5 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 815890826
• NCBI GeneID: 6584
• NCBI Accession #: NP_001295051.1
• NCBI GenBank Nucleotide #: NM_001308122.1
• UniProt Accession #: O76082; Q6ZQZ8; Q96EH6; A2Q0V1; B2R844; D3DQ87
• Molecular Weight: 65,327 Da
• NCBI Official Full Name: solute carrier family 22 member 5 isoform a
• NCBI Official Synonym Full Names: solute carrier family 22 (organic cation/carnitine transporter), member 5
• NCBI Official Symbol: SLC22A5
• NCBI Official Synonym Symbols: CDSP; OCTN2
• NCBI Protein Information: solute carrier family 22 member 5
• UniProt Protein Name: Solute carrier family 22 member 5
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC22A5
• UniProt Synonym Gene Names: OCTN2
• UniProt Entry Name: S22A5_HUMAN

NCBI Description

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Uniprot Description

SLC22A5: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. Defects in SLC22A5 are the cause of systemic primary carnitine deficiency (CDSP). CDSP is an autosomal recessive disorder of fatty acid oxidation caused by defective carnitine transport. Present early in life with hypoketotic hypoglycemia and acute metabolic decompensation, or later in life with skeletal myopathy or cardiomyopathy. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q23.3

Cellular Component: basolateral plasma membrane; brush border membrane; apical plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; antibiotic transporter activity; symporter activity; carnitine transporter activity; drug transporter activity; quaternary ammonium group transmembrane transporter activity; ATP binding; PDZ domain binding

Biological Process: quaternary ammonium group transport; drug transport; antibiotic transport; sodium ion transport; multidrug transport; transmembrane transport; carnitine transport; quorum sensing during interaction with host

Disease: Carnitine Deficiency, Systemic Primary