Rabbit SLC19A3 Polyclonal Antibody | anti-SLC19A3 antibody

SLC19A3 Antibody

Cat. Num. AAA9611492

• Gene Names: SLC19A3; BBGD; THMD2; THTR2; thTr-2
• Reactivity: Human; Mouse; Rat
• Applications: Western Blot
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: SLC19A3; Polyclonal Antibody; SLC19A3 Antibody; SLC19A3 Antibody - Internal; Solute carrier family 19 member 3; Thiamine transporter 2; thTr 2; THTR2;; anti-SLC19A3 antibody

• Host: Rabbit
• Reactivity: Human; Mouse; Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: SLC19A3 Antibody detects endogenous levels of SLC19A3.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 496

• Applicable Applications for anti-SLC19A3 antibody: Western Blot (WB)
• Application Notes: WB 1:500-1:2000
• Immunogen: A synthesized peptide derived from human SLC19A3.
• Fragment: Fab fragment
• Conjugation: Unconjugated
• Storage Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C. Stable for 12 months from date of receipt.
• Preparation and Storage: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 degree C. Stable for 12 months from date of receipt.

Related Product Information for anti-SLC19A3 antibody

Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.

Similarity: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. [View classification]

NCBI and Uniprot Product Information

• NCBI GI #: 13376856
• NCBI GeneID: 80704
• NCBI Accession #: NP_079519.1
• NCBI GenBank Nucleotide #: NP_079519.1
• UniProt Accession #: Q9BZV2
• Molecular Weight: Observed Mol.Wt.: 66 kDa. Predicted Mol.Wt.: 56kDa.
• NCBI Official Full Name: thiamine transporter 2 isoform 1
• NCBI Official Synonym Full Names: solute carrier family 19 member 3
• NCBI Official Symbol: SLC19A3
• NCBI Official Synonym Symbols: BBGD; THMD2; THTR2; thTr-2
• NCBI Protein Information: thiamine transporter 2
• UniProt Protein Name: Thiamine transporter 2
• Protein Family: Thiamine transporter
• UniProt Gene Name: SLC19A3
• UniProt Synonym Gene Names: ThTr-2; ThTr2
• UniProt Entry Name: S19A3_HUMAN

NCBI Description

This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild cognitive disability, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy.[provided by RefSeq, Jan 2010]