Rabbit SLC19A3 Polyclonal Antibody | anti-SLC19A3 antibody

SLC19A3 Rabbit Polyclonal

Cat. Num. AAA7604148

• Gene Names: SLC19A3; BBGD; THMD2; THTR2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: Purification: Immunogen affinity purified; Purity: > = 95% as determined by SDS-PAGE
• Synonyms: SLC19A3; Polyclonal Antibody; SLC19A3 Rabbit Polyclonal; anti-SLC19A3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purification: Immunogen affinity purified; Purity: > = 95% as determined by SDS-PAGE
• Form/Format: Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3
• Sequence Length: 496

• Applicable Applications for anti-SLC19A3 antibody: ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: WB: 1:500-1:2000; IP: 1:200-1:2000
• Immunogen: Solute carrier family 19, member 3
• Preparation and Storage: Store at -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Immunoprecipitation (IP)

(IP Result of anti-SLC19A3 (IP: MBS7604148, 4ug; Detection: MBS7604148 1:600) with mouse liver tissue lysate 4000ug.)

Western Blot (WB)

(Mouse liver tissue were subjected to SDS PAGE followed by western blot with MBS7604148 (SLC19A3 Antibody) at dilution of 1:600)

Related Product Information for anti-SLC19A3 antibody

Mediates high affinity thiamine uptake, propably via a proton anti-port mechanism. Has no folate transport activity.

NCBI and Uniprot Product Information

• NCBI GI #: 823671942
• NCBI GeneID: 80704
• UniProt Accession #: Q9BZV2
• Molecular Weight: 63-66 kDa
• NCBI Official Full Name: SLC19A3, partial
• NCBI Official Synonym Full Names: solute carrier family 19 member 3
• NCBI Official Symbol: SLC19A3
• NCBI Official Synonym Symbols: BBGD; THMD2; THTR2
• NCBI Protein Information: thiamine transporter 2
• UniProt Protein Name: Thiamine transporter 2
• Protein Family: Thiamine transporter
• UniProt Gene Name: SLC19A3
• UniProt Synonym Gene Names: ThTr-2; ThTr2
• UniProt Entry Name: S19A3_HUMAN

NCBI Description

This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild mental retardation, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy.[provided by RefSeq, Jan 2010]

Uniprot Description

SLC19A3: Mediates high affinity thiamine uptake, propably via a proton anti-port mechanism. Has no folate transport activity. Defects in SLC19A3 are the cause of biotin-responsive basal ganglia disease (BBGD). BBGD is a recessive disorder with childhood onset that presents as a subacute encephalopathy, with confusion, dysarthria, and dysphagia, and that progresses to severe rigidity, dystonia, quadriparesis and death if not treated. Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.

Protein type: Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: thiamin transmembrane transporter activity; thiamin uptake transmembrane transporter activity

Biological Process: thiamin and derivative metabolic process

Disease: Thiamine Metabolism Dysfunction Syndrome 2 (biotin- Or Thiamine-responsive Type)