Sheep SERPINB8 Polyclonal Antibody | anti-SERPINB8 antibody

SERPINB8 (Serine/Cysteine Proteinase Inhibitor, Clade B, Member 8, NK10, PI8)

Cat. Num. AAA647794

• Gene Names: SERPINB8; PI8; CAP2
• Applications: ELISA, Immunoprecipitation, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: SERPINB8; Polyclonal Antibody; SERPINB8 (Serine/Cysteine Proteinase Inhibitor; Clade B; Member 8; NK10; PI8); Anti -SERPINB8 (Serine/Cysteine Proteinase Inhibitor; anti-SERPINB8 antibody

• Host: Sheep
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Serpin A9.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder in PBS with 5% trehalose. Reconstitute with sterile PBS.

• Applicable Applications for anti-SERPINB8 antibody: ELISA (EL/EIA), Immunoprecipitation (IP), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Immunoprecipitation and Immunohistochemistry.; Dilution: Direct ELISA: 0.5-1.0ug/ml; Immunohistochemistry: 3-10ug/ml
• Immunogen: Recombinant corresponding to human Serpin A9 expressed in NSO cells (AAQ89063).
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-SERPINB8 antibody

Serpin A9 (Serine proteinase inhibitor-clade A #9; also GCET1, Centerin and Serpin A11) is a 46 kD, secreted member of the a1-antitrypsin (clade A)-subfamily, serpin superfamily of protease inhibitors. It is only produced by normal and lymphoma germinal center B cells. Its function is unknown, but it presumably acts as an inhibitor of a trypsin-like protease. Mature human Serpin A9 is presumably 394aa in length. It contains one Serpin motif (aa405-415). There are multiple splice variants associated with Serpin A9. There are alternate start sites at Met19, Met99 and Met150. A fourth isoform shows a two aa substitution for (aa369-435), while a fifth isoform shares this same substitution coupled with a 39aa substitution for (aa1-75). A sixth variant shows a deletion of (aa91-190). Mature human Serpin A9 shares 67% aa identity with mouse Serpin A9.

Product Categories/Family for anti-SERPINB8 antibody

Antibodies; Abs to Protease Inhibitors

NCBI and Uniprot Product Information

• NCBI GI #: 451770404
• NCBI GeneID: 5271
• NCBI Accession #: NP_001263419.1
• NCBI GenBank Nucleotide #: NM_001276490.1
• UniProt Accession #: P50452; Q7Z2V6; Q8N178
• Molecular Weight: 42,767 Da
• NCBI Official Full Name: serpin B8 isoform c
• NCBI Official Synonym Full Names: serpin peptidase inhibitor, clade B (ovalbumin), member 8
• NCBI Official Symbol: SERPINB8
• NCBI Official Synonym Symbols: PI8; CAP2
• NCBI Protein Information: serpin B8; PI-8; peptidase inhibitor 8; cytoplasmic antiproteinase 2; protease inhibitor 8 (ovalbumin type); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8
• UniProt Protein Name: Serpin B8
• Protein Family: Serpin
• UniProt Gene Name: SERPINB8
• UniProt Synonym Gene Names: PI8; CAP-2; CAP2; PI-8
• UniProt Entry Name: SPB8_HUMAN

NCBI Description

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]

Uniprot Description

Subcellular location: Cytoplasm.

Sequence similarities: Belongs to the serpin family. Ov-serpin subfamily.