Rabbit anti-Mouse SerpinA10 Polyclonal Antibody | anti-SerpinA10 antibody

Anti-SerpinA10 Antibody, Rabbit Polyclonal

Cat. Num. AAA8111372

• Gene Names: Serpina10; PZI; ZPI
• Reactivity: Mouse
• Applications: ELISA
• Purity: Protein A & Antigen Affinity
• Synonyms: SerpinA10; Polyclonal Antibody; Anti-SerpinA10 Antibody; Rabbit Polyclonal; SerpinA10 Antibody; Rabbit PAb; Antigen Affinity Purified; serpin peptidase inhibitor; clade A (alpha-1 antiproteinase; antitrypsin); member 10; Anti-PZI Antibody; Anti-Serpin A10 Antibody; Anti-ZPI Antibody; anti-SerpinA10 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse SerpinA10
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-SerpinA10 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:5000-1:10,000
• Immunogen: Recombinant Mouse SerpinA10 protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Mouse SerpinA10 (rM SerpinA10). SerpinA10 specific IgG was purified by Mouse SerpinA10 affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-SerpinA10 antibody

Protein Z-dependent protease inhibitor, also known as PZ-dependent protease inhibitor, SERPINA1 and ZPI, is a secreted protein that belongs to the serpin family. It is expressed by the liver and secreted in plasma. SERPINA1/Serpin-A1 inhibits factor Xa activity in the presence of protein Z, calcium and phospholipid. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors). Over 1 serpins have now been identified, these include 36 human proteins, as well as molecules in plants, fungi, bacteria, archaea and certain viruses. Serpins are the largest and most diverse family of protease inhibitors. Most serpins control proteolytic cascades, certain serpins do not inhibit enzymes, but instead perform diverse functions such as storage (ovalbumin, in egg white), hormone carriage proteins (thyroxine-binding globulin, cortisol-binding globulin) and tumor suppressor genes (maspin). Most inhibitory serpins target chymotrypsin-like serine proteases. These enzymes are defined by the presence of a nucleophilic serine residue in their catalytic site. Some serpins inhibit other classes of protease. A number of such serpins have been shown to target cysteine proteases. These enzymes differ from serine proteases in that they are defined by the presence of a nucleophilic cysteine residue, rather than a serine residue, in their catalytic site.

References

Han X, et al., 1998, Proc Natl Acad Sci. USA 95: 9250-5. Han X, et al., 2000, Blood 96: 3049-55. Irving JA, et al., 2000, Genome Res. 10 (12): 1845-64. Irving J, et al., 2002, Mol Biol Evol. 19 (11): 1881-90. Rawlings ND, et al., 2004, Biochem J. 378 (Pt 3): 705-16. Water N, et al., 2004, Br J Haematol. 127:190-4. Wei Z, et al., 2009, Blood 114 (17): 3662-7. Whisstock JC, et al., 2010, J Biol Chem. 285 (32): 24307-12.

NCBI and Uniprot Product Information

• NCBI GI #: 31981720
• NCBI GeneID: 217847
• NCBI Accession #: NP_659083.2
• NCBI GenBank Nucleotide #: NM_144834.3
• UniProt Accession #: Q8R121; Q8VCV8
• Molecular Weight: 160,000
• NCBI Official Full Name: protein Z-dependent protease inhibitor
• NCBI Official Synonym Full Names: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
• NCBI Official Symbol: Serpina10
• NCBI Official Synonym Symbols: PZI; ZPI
• NCBI Protein Information: protein Z-dependent protease inhibitor; serpin A10; PZ-dependent protease inhibitor; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
• UniProt Protein Name: Protein Z-dependent protease inhibitor
• Protein Family: Protein Z-dependent protease inhibitor
• UniProt Gene Name: Serpina10
• UniProt Synonym Gene Names: Zpi; PZ-dependent protease inhibitor; PZI
• UniProt Entry Name: ZPI_MOUSE

NCBI Description

The protein encoded by this gene is a member of the large serpin family of proteins, and is also known as serpin PZ-dependent protease inhibitor (ZPI or PZI). This protein is thought to play an important role in the regulation of coagulation. It directly inhibits factor XIa, and also inhibits factor Xa in the presence of calcium, phospholipids, and protein Z (PZ). Deficiencies in this gene lead to an increase in thrombosis. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Aug 2014]

Uniprot Description

SERPINA10: Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; protease inhibitor activity

Biological Process: hemostasis; negative regulation of peptidase activity; blood coagulation