Rabbit anti-Human Serine/threonine-protein kinase TBK1 Polyclonal Antibody | anti-TBK1 antibody

Rabbit anti-human Serine/threonine-protein kinase TBK1 polyclonal Antibody; FITC conjugated

Cat. Num. AAA1490532

• Gene Names: TBK1; NAK; T2K
• Reactivity: Human
• Applications: ELISA
• Purity: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Synonyms: Serine/threonine-protein kinase TBK1; Polyclonal Antibody; Rabbit anti-human Serine/threonine-protein kinase TBK1 polyclonal Antibody; FITC conjugated; NF-kappa-B-activating kinase T2K TANK-binding kinase 1 TBK1 NAK; anti-TBK1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Form/Format: Liquid
• Sequence Length: 729

• Applicable Applications for anti-TBK1 antibody: ELISA (EIA)
• Immunogen: Recombinant human Serine/threonine-protein kinase TBK1 protein
• Relevance: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein.
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: FITC conjugated
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-33895 / sc-33896 / sc-33897 / sc-7221
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

NCBI and Uniprot Product Information

• NCBI GI #: 7019547
• NCBI GeneID: 29110
• NCBI Accession #: NP_037386.1
• NCBI GenBank Nucleotide #: NM_013254.3
• UniProt Accession #: Q9UHD2; Q8IYV3; Q9NUJ5; A8K4S4
• Molecular Weight: 83,642 Da
• NCBI Official Full Name: serine/threonine-protein kinase TBK1
• NCBI Official Synonym Full Names: TANK-binding kinase 1
• NCBI Official Symbol: TBK1
• NCBI Official Synonym Symbols: NAK; T2K
• NCBI Protein Information: serine/threonine-protein kinase TBK1; NF-kB-activating kinase; NF-kappa-B-activating kinase
• UniProt Protein Name: Serine/threonine-protein kinase TBK1
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: TBK1
• UniProt Synonym Gene Names: NAK
• UniProt Entry Name: TBK1_HUMAN

NCBI Description

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010]

Uniprot Description

TBK1: a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

Protein type: Protein kinase, Other; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; IKK family

Chromosomal Location of Human Ortholog: 12q14.1

Cellular Component: cytoplasm; endosome membrane; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; nucleic acid binding; phosphoprotein binding; ATP binding; protein kinase activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; response to virus; MyD88-independent toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; positive regulation of peptidyl-serine phosphorylation; protein amino acid phosphorylation; defense response to Gram-positive bacterium; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; toll-like receptor signaling pathway; positive regulation of interferon type I production; innate immune response; interferon type I production; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; toll-like receptor 4 signaling pathway; defense response to virus; negative regulation of interferon type I production; positive regulation of interferon-alpha production

Disease: Frontotemporal Dementia And/or Amyotrophic Lateral Sclerosis 4